Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats
This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make c...
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MDPI AG
2022-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/10/1992 |
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| author | Aleksey Bychkov Vyacheslav Koptev Varvara Zaharova Polina Reshetnikova Elena Trofimova Elena Bychkova Ekaterina Podgorbunskikh Oleg Lomovsky |
| author_facet | Aleksey Bychkov Vyacheslav Koptev Varvara Zaharova Polina Reshetnikova Elena Trofimova Elena Bychkova Ekaterina Podgorbunskikh Oleg Lomovsky |
| author_sort | Aleksey Bychkov |
| collection | DOAJ |
| description | This study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts). |
| first_indexed | 2024-03-10T03:15:28Z |
| format | Article |
| id | doaj.art-8a70877d4e05435baea20c7074f909b6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:15:28Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8a70877d4e05435baea20c7074f909b62023-11-23T12:28:16ZengMDPI AGNutrients2072-66432022-05-011410199210.3390/nu14101992Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and RatsAleksey Bychkov0Vyacheslav Koptev1Varvara Zaharova2Polina Reshetnikova3Elena Trofimova4Elena Bychkova5Ekaterina Podgorbunskikh6Oleg Lomovsky7Scientific Department, Moscow State University of Food Production, 11 Volokolamskoe Hwy., 125080 Moscow, RussiaLaboratory of Young Animal Diseases, Siberian Federal Scientific Center of Agro-Biotechnologies RAS, 2b Centralnaya, 630501 Novosibirsk, RussiaLaboratory of Young Animal Diseases, Siberian Federal Scientific Center of Agro-Biotechnologies RAS, 2b Centralnaya, 630501 Novosibirsk, RussiaDepartment of Business, Novosibirsk State Technical University, 20 Prospekt K. Marksa, 630073 Novosibirsk, RussiaLaboratory of Mechanochemistry, Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630090 Novosibirsk, RussiaDepartment of Business, Novosibirsk State Technical University, 20 Prospekt K. Marksa, 630073 Novosibirsk, RussiaLaboratory of Mechanochemistry, Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630090 Novosibirsk, RussiaLaboratory of Mechanochemistry, Institute of Solid State Chemistry and Mechanochemistry SB RAS, 18 Kutateladze, 630090 Novosibirsk, RussiaThis study presents findings on the biological action of an integrated supplement containing the following components involved in osteogenesis and mineralization: vitamin D and silicon in the bioavailable and soluble form. A hypothesis that these components potentiate one another’s action and make calcium absorption by the body more efficient was tested. Biological tests of the effect of vitamin D and silicon chelates on bone fracture healing and bone turnover were conducted using ICR mice and albino Wistar rats. Radiographic and biochemical studies show that the supplement simultaneously containing silicon chelates and vitamin D stimulates bone tissue regeneration upon mechanical defects and accelerates differentiation of osteogenic cells, regeneration of spongy and compact bones, and restoration of bone structure due to activation of osteoblast performance. Bone structure restoration was accompanied by less damage to skeletal bones, apparently due to better absorption of calcium from food. The studied supplement has a similar effect when used to manage physiologically induced decalcification, thus holding potential for the treatment of osteomalacia during pregnancy or occupational diseases (e.g., for managing bone decalcification in astronauts).https://www.mdpi.com/2072-6643/14/10/1992siliconsilicon chelatevitamin Dmechanochemistrybonefracture healing |
| spellingShingle | Aleksey Bychkov Vyacheslav Koptev Varvara Zaharova Polina Reshetnikova Elena Trofimova Elena Bychkova Ekaterina Podgorbunskikh Oleg Lomovsky Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats Nutrients silicon silicon chelate vitamin D mechanochemistry bone fracture healing |
| title | Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats |
| title_full | Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats |
| title_fullStr | Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats |
| title_full_unstemmed | Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats |
| title_short | Experimental Testing of the Action of Vitamin D and Silicon Chelates in Bone Fracture Healing and Bone Turnover in Mice and Rats |
| title_sort | experimental testing of the action of vitamin d and silicon chelates in bone fracture healing and bone turnover in mice and rats |
| topic | silicon silicon chelate vitamin D mechanochemistry bone fracture healing |
| url | https://www.mdpi.com/2072-6643/14/10/1992 |
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