Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Although idiopathic PD accounts for most of the cases, several genetic mutations have been found to cause PD. Mutations in the eukaryotic translation initiation factor 4-γ, 1 (EIF4G1) gene have been identif...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664615002764 |
| _version_ | 1819093963259248640 |
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| author | Yi Ching Weng Chiung Mei Chen Yi Chun Chen Hon Chung Fung Chia Wen Chang Kuo Hsuan Chang Yih Ru Wu |
| author_facet | Yi Ching Weng Chiung Mei Chen Yi Chun Chen Hon Chung Fung Chia Wen Chang Kuo Hsuan Chang Yih Ru Wu |
| author_sort | Yi Ching Weng |
| collection | DOAJ |
| description | Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Although idiopathic PD accounts for most of the cases, several genetic mutations have been found to cause PD. Mutations in the eukaryotic translation initiation factor 4-γ, 1 (EIF4G1) gene have been identified since 2011, which were reported to be associated with PD among Caucasians in subsequent research. However, this observation was not consistent. The contribution to other ethnic groups remains limited, with < 1% of sporadic cases. We conducted a case–control study to analyze if EIF4G1 is a risk factor for PD patients in Taiwan.
Methods: There were 595 PD patients and 600 controls without neurological diseases enrolled in this study. Four reported mutations—A502V (c.1505C>T), G686C (c.2056 G>T), R1197W (c.3589C>T), and R1205H (c.3614G>A)—were analyzed.
Results: There were no mutations found in either PD patients or controls.
Conclusion: This study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in PD. Further large scale studies are warranted to evaluate the association of PD and EIF4G1 gene. |
| first_indexed | 2024-12-21T23:19:51Z |
| format | Article |
| id | doaj.art-8a70a932a84e41699e585970a80e342f |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-21T23:19:51Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-8a70a932a84e41699e585970a80e342f2022-12-21T18:46:49ZengElsevierJournal of the Formosan Medical Association0929-66462016-09-01115972873310.1016/j.jfma.2015.07.020Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among TaiwaneseYi Ching WengChiung Mei ChenYi Chun ChenHon Chung FungChia Wen ChangKuo Hsuan ChangYih Ru WuParkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Although idiopathic PD accounts for most of the cases, several genetic mutations have been found to cause PD. Mutations in the eukaryotic translation initiation factor 4-γ, 1 (EIF4G1) gene have been identified since 2011, which were reported to be associated with PD among Caucasians in subsequent research. However, this observation was not consistent. The contribution to other ethnic groups remains limited, with < 1% of sporadic cases. We conducted a case–control study to analyze if EIF4G1 is a risk factor for PD patients in Taiwan. Methods: There were 595 PD patients and 600 controls without neurological diseases enrolled in this study. Four reported mutations—A502V (c.1505C>T), G686C (c.2056 G>T), R1197W (c.3589C>T), and R1205H (c.3614G>A)—were analyzed. Results: There were no mutations found in either PD patients or controls. Conclusion: This study indicates that the EIF4G1 mutation is rare in Taiwan, which is consistent with other reports from Asia. Ethnicity could have a great influence on EIF4G1 in PD. Further large scale studies are warranted to evaluate the association of PD and EIF4G1 gene.http://www.sciencedirect.com/science/article/pii/S0929664615002764eukaryotic translation initiation factor 4-γ, 1mutationsParkinson's disease |
| spellingShingle | Yi Ching Weng Chiung Mei Chen Yi Chun Chen Hon Chung Fung Chia Wen Chang Kuo Hsuan Chang Yih Ru Wu Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese Journal of the Formosan Medical Association eukaryotic translation initiation factor 4-γ, 1 mutations Parkinson's disease |
| title | Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese |
| title_full | Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese |
| title_fullStr | Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese |
| title_full_unstemmed | Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese |
| title_short | Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese |
| title_sort | eukaryotic translation initiation factor 4 γ 1 gene mutations are rare in parkinson s disease among taiwanese |
| topic | eukaryotic translation initiation factor 4-γ, 1 mutations Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S0929664615002764 |
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