Mortality in hospitalized patients with tuberculous meningitis
Abstract Background To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality. Methods Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generali...
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3633-4 |
| _version_ | 1818601906690326528 |
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| author | Jaime Soria Tatiana Metcalf Nicanor Mori Renee E. Newby Silvia M. Montano Luz Huaroto Eduardo Ticona Joseph R. Zunt |
| author_facet | Jaime Soria Tatiana Metcalf Nicanor Mori Renee E. Newby Silvia M. Montano Luz Huaroto Eduardo Ticona Joseph R. Zunt |
| author_sort | Jaime Soria |
| collection | DOAJ |
| description | Abstract Background To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality. Methods Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generalized linear regression to identify factors predictive of in-hospital mortality. Results Of 263 patients, the median age was 35 years, 72.6% were men, 38% were positive for HIV upon admission, 24% had prior TB infections and 2.3% had prior MDR-TB infections. In-hospital mortality was 30.4% of all study patients with a final diagnosis of TBM. When multivariable analysis was applied, significant associations with in-hospital mortality were seen among patients with HIV (RR 2.06; Confidence Interval 95% (95% CI) 1.44–2.94), BMRC II (RR 1.78; 95% CI 1.07–2.97), BMRC III (RR 3.11; 95% CI 1.78–5.45) and positive CSF cultures (RR 1.95; 95% CI 1.39–2.74). Conclusions In-hospital mortality is higher among patients with HIV infections, age over 40 years, positive CSF TB culture and BMRC stage II or III. |
| first_indexed | 2024-12-16T12:58:50Z |
| format | Article |
| id | doaj.art-8a70d8b1aeee4ae2a83614fa50532c6a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-16T12:58:50Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-8a70d8b1aeee4ae2a83614fa50532c6a2022-12-21T22:30:55ZengBMCBMC Infectious Diseases1471-23342019-01-011911710.1186/s12879-018-3633-4Mortality in hospitalized patients with tuberculous meningitisJaime Soria0Tatiana Metcalf1Nicanor Mori2Renee E. Newby3Silvia M. Montano4Luz Huaroto5Eduardo Ticona6Joseph R. Zunt7Infectious and Tropical Diseases Department, Hospital Nacional Dos de MayoFaculty of Tropical Medicine, Mahidol UniversityUniversidad Nacional Mayor de San MarcosNorthern Pacific Global Health Research Fellows Training Consortium, University of WashingtonUniversidad Nacional Mayor de San MarcosInfectious and Tropical Diseases Department, Hospital Nacional Dos de MayoInfectious and Tropical Diseases Department, Hospital Nacional Dos de MayoDepartments of Neurology, Global Health, Medicine and Epidemiology, University of WashingtonAbstract Background To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality. Methods Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generalized linear regression to identify factors predictive of in-hospital mortality. Results Of 263 patients, the median age was 35 years, 72.6% were men, 38% were positive for HIV upon admission, 24% had prior TB infections and 2.3% had prior MDR-TB infections. In-hospital mortality was 30.4% of all study patients with a final diagnosis of TBM. When multivariable analysis was applied, significant associations with in-hospital mortality were seen among patients with HIV (RR 2.06; Confidence Interval 95% (95% CI) 1.44–2.94), BMRC II (RR 1.78; 95% CI 1.07–2.97), BMRC III (RR 3.11; 95% CI 1.78–5.45) and positive CSF cultures (RR 1.95; 95% CI 1.39–2.74). Conclusions In-hospital mortality is higher among patients with HIV infections, age over 40 years, positive CSF TB culture and BMRC stage II or III.http://link.springer.com/article/10.1186/s12879-018-3633-4TuberculosisMeningitisHIV |
| spellingShingle | Jaime Soria Tatiana Metcalf Nicanor Mori Renee E. Newby Silvia M. Montano Luz Huaroto Eduardo Ticona Joseph R. Zunt Mortality in hospitalized patients with tuberculous meningitis BMC Infectious Diseases Tuberculosis Meningitis HIV |
| title | Mortality in hospitalized patients with tuberculous meningitis |
| title_full | Mortality in hospitalized patients with tuberculous meningitis |
| title_fullStr | Mortality in hospitalized patients with tuberculous meningitis |
| title_full_unstemmed | Mortality in hospitalized patients with tuberculous meningitis |
| title_short | Mortality in hospitalized patients with tuberculous meningitis |
| title_sort | mortality in hospitalized patients with tuberculous meningitis |
| topic | Tuberculosis Meningitis HIV |
| url | http://link.springer.com/article/10.1186/s12879-018-3633-4 |
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