Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis
Atopic dermatitis (AD) is a refractory and relapsing skin disease with a complex and multifactorial etiology. Various congenital malformations and environmental factors are thought to be involved in the onset of the disease. The etiology of the disease has been investigated, with respect to clinical...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/8/4228 |
| _version_ | 1797537132237029376 |
|---|---|
| author | Dong Hoon Park Joo Wan Kim Hi-Joon Park Dae-Hyun Hahm |
| author_facet | Dong Hoon Park Joo Wan Kim Hi-Joon Park Dae-Hyun Hahm |
| author_sort | Dong Hoon Park |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a refractory and relapsing skin disease with a complex and multifactorial etiology. Various congenital malformations and environmental factors are thought to be involved in the onset of the disease. The etiology of the disease has been investigated, with respect to clinical skin symptoms and systemic immune response factors. A gut microbiome–mediated connection between emotional disorders such as depression and anxiety, and dermatologic conditions such as acne, based on the comorbidities of these two seemingly unrelated disorders, has long been hypothesized. Many aspects of this gut–brain–skin integration theory have recently been revalidated to identify treatment options for AD with the recent advances in metagenomic analysis involving powerful sequencing techniques and bioinformatics that overcome the need for isolation and cultivation of individual microbial strains from the skin or gut. Comparative analysis of microbial clusters across the gut–skin axis can provide new information regarding AD research. Herein, we provide a historical perspective on the modern investigation and clinical implications of gut–skin connections in AD in terms of the integration between the two microbial clusters. |
| first_indexed | 2024-03-10T12:11:39Z |
| format | Article |
| id | doaj.art-8a719c3024d8420caa184f8d10f7a4e1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:11:39Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8a719c3024d8420caa184f8d10f7a4e12023-11-21T16:12:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228422810.3390/ijms22084228Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic DermatitisDong Hoon Park0Joo Wan Kim1Hi-Joon Park2Dae-Hyun Hahm3College of Medicine, Kyung Hee University, Seoul 02447, KoreaCollege of Medicine, Kyung Hee University, Seoul 02447, KoreaAcupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 02447, KoreaCollege of Medicine, Kyung Hee University, Seoul 02447, KoreaAtopic dermatitis (AD) is a refractory and relapsing skin disease with a complex and multifactorial etiology. Various congenital malformations and environmental factors are thought to be involved in the onset of the disease. The etiology of the disease has been investigated, with respect to clinical skin symptoms and systemic immune response factors. A gut microbiome–mediated connection between emotional disorders such as depression and anxiety, and dermatologic conditions such as acne, based on the comorbidities of these two seemingly unrelated disorders, has long been hypothesized. Many aspects of this gut–brain–skin integration theory have recently been revalidated to identify treatment options for AD with the recent advances in metagenomic analysis involving powerful sequencing techniques and bioinformatics that overcome the need for isolation and cultivation of individual microbial strains from the skin or gut. Comparative analysis of microbial clusters across the gut–skin axis can provide new information regarding AD research. Herein, we provide a historical perspective on the modern investigation and clinical implications of gut–skin connections in AD in terms of the integration between the two microbial clusters.https://www.mdpi.com/1422-0067/22/8/4228atopic dermatitisskin microbiomegut microbiomegut–skin axis |
| spellingShingle | Dong Hoon Park Joo Wan Kim Hi-Joon Park Dae-Hyun Hahm Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis International Journal of Molecular Sciences atopic dermatitis skin microbiome gut microbiome gut–skin axis |
| title | Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis |
| title_full | Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis |
| title_fullStr | Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis |
| title_full_unstemmed | Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis |
| title_short | Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis |
| title_sort | comparative analysis of the microbiome across the gut skin axis in atopic dermatitis |
| topic | atopic dermatitis skin microbiome gut microbiome gut–skin axis |
| url | https://www.mdpi.com/1422-0067/22/8/4228 |
| work_keys_str_mv | AT donghoonpark comparativeanalysisofthemicrobiomeacrossthegutskinaxisinatopicdermatitis AT joowankim comparativeanalysisofthemicrobiomeacrossthegutskinaxisinatopicdermatitis AT hijoonpark comparativeanalysisofthemicrobiomeacrossthegutskinaxisinatopicdermatitis AT daehyunhahm comparativeanalysisofthemicrobiomeacrossthegutskinaxisinatopicdermatitis |