Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications
Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus,...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/7/611 |
| _version_ | 1797562704576118784 |
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| author | Rafaela Freitas Alice Martins Joana Silva Celso Alves Susete Pinteus Joana Alves Fernando Teodoro Helena Margarida Ribeiro Lídia Gonçalves Željko Petrovski Luís Branco Rui Pedrosa |
| author_facet | Rafaela Freitas Alice Martins Joana Silva Celso Alves Susete Pinteus Joana Alves Fernando Teodoro Helena Margarida Ribeiro Lídia Gonçalves Željko Petrovski Luís Branco Rui Pedrosa |
| author_sort | Rafaela Freitas |
| collection | DOAJ |
| description | Skin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed <i>Fucus spiralis</i>. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC<sub>50</sub> of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H<sub>2</sub>O<sub>2</sub> (IC<sub>50</sub> of 41.3 µg/mL) and by UVB (IC<sub>50</sub> of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of <i>F. spiralis</i> for further dermatological applications. |
| first_indexed | 2024-03-10T18:31:40Z |
| format | Article |
| id | doaj.art-8a727de2e3fd47f18fcbc24e0c06144a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T18:31:40Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8a727de2e3fd47f18fcbc24e0c06144a2023-11-20T06:32:30ZengMDPI AGAntioxidants2076-39212020-07-019761110.3390/antiox9070611Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin ApplicationsRafaela Freitas0Alice Martins1Joana Silva2Celso Alves3Susete Pinteus4Joana Alves5Fernando Teodoro6Helena Margarida Ribeiro7Lídia Gonçalves8Željko Petrovski9Luís Branco10Rui Pedrosa11MARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-038 Lisboa, PortugalResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-038 Lisboa, PortugalDepartamento de Química, REQUIMTE-CQFB, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, PortugalDepartamento de Química, REQUIMTE-CQFB, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, 2829-516 Caparica, PortugalMARE—Marine and Environmental Sciences Centre, ESTM, Politécnico de Leiria, 2520-641 Peniche, PortugalSkin aging is a biological process influenced by intrinsic and extrinsic factors. The last ones, mainly exposure to UV radiation, increases reactive oxygen species (ROS) production leading to a loss of extracellular matrix, also enhanced by enzymatic degradation of matrix supporting molecules. Thus, and with the growing demand for eco-friendly skin products, natural compounds extracted from brown seaweeds revealed to be good candidates due to their broad range of bioactivities, especially as antioxidants. The aim of this study was to assess the dermo-cosmetic potential of different fractions obtained from the brown seaweed <i>Fucus spiralis</i>. For this purpose, in vitro antioxidant (Total Phenolic Content (TPC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Absorbance Capacity (ORAC)), anti-enzymatic (collagenase, elastase and hyaluronidase), antimicrobial, anti-inflammatory (NO production) and photoprotective (ROS production) capacities were evaluated. Although nearly all fractions evidenced antioxidant effects, fraction F10 demonstrated the highest antioxidant ability (EC<sub>50</sub> of 38.5 µg/mL, DPPH assay), and exhibited a strong effect as an inhibitor of collagenase (0.037 µg/mL) and elastase (3.0 µg/mL). Moreover, this fraction was also the most potent on reducing ROS production promoted by H<sub>2</sub>O<sub>2</sub> (IC<sub>50</sub> of 41.3 µg/mL) and by UVB (IC<sub>50</sub> of 31.3 µg/mL). These bioactivities can be attributed to its high content of phlorotannins, as evaluated by LC-MS analysis, reinforcing the potential of <i>F. spiralis</i> for further dermatological applications.https://www.mdpi.com/2076-3921/9/7/611<i>Fucus spiralis</i>seaweedsantioxidantoxidative stressphotoprotectiveanti-enzymatic |
| spellingShingle | Rafaela Freitas Alice Martins Joana Silva Celso Alves Susete Pinteus Joana Alves Fernando Teodoro Helena Margarida Ribeiro Lídia Gonçalves Željko Petrovski Luís Branco Rui Pedrosa Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications Antioxidants <i>Fucus spiralis</i> seaweeds antioxidant oxidative stress photoprotective anti-enzymatic |
| title | Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications |
| title_full | Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications |
| title_fullStr | Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications |
| title_full_unstemmed | Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications |
| title_short | Highlighting the Biological Potential of the Brown Seaweed <i>Fucus spiralis</i> for Skin Applications |
| title_sort | highlighting the biological potential of the brown seaweed i fucus spiralis i for skin applications |
| topic | <i>Fucus spiralis</i> seaweeds antioxidant oxidative stress photoprotective anti-enzymatic |
| url | https://www.mdpi.com/2076-3921/9/7/611 |
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