The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is related to the vascular oxidative and nitrosative stress, the trigger for atherosclerosis and cardiovascular complications. The effects of moderate swimming training associated with quercetin oral administration were evaluated in aorta of rats with experimentally induced...
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MDPI AG
2023-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/5/586 |
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| author | Irina-Camelia Chis Carmen-Maria Micu Alina Toader Remus Moldovan Laura Lele Simona Clichici Daniela-Rodica Mitrea |
| author_facet | Irina-Camelia Chis Carmen-Maria Micu Alina Toader Remus Moldovan Laura Lele Simona Clichici Daniela-Rodica Mitrea |
| author_sort | Irina-Camelia Chis |
| collection | DOAJ |
| description | Type 1 diabetes mellitus is related to the vascular oxidative and nitrosative stress, the trigger for atherosclerosis and cardiovascular complications. The effects of moderate swimming training associated with quercetin oral administration were evaluated in aorta of rats with experimentally induced type 1 diabetes mellitus (T1DM), by analysing the nitric oxide-endothelial dependent relaxation (NO-EDR). T1DM rats received daily quercetin 30 mg/kg and followed the protocol of 5-weeks swimming exercise (30 min/day; 5 days/week). Aorta relaxation to acetylcholine (Ach) and sodium nitroprusside (SNP) were measured at the end of the experiment. Ach-induced endothelial dependent relaxation was significantly decreased in phenylephrine (PE) pre-contracted aorta of diabetic rats. Swimming exercise with quercetin administration preserved Ach-induced EDR but did not have any impact on SNP-induced endothelium-independent relaxation in the diabetic aorta. These findings suggest that quercetin administration associated with moderate swimming exercise could improve the endothelial NO-dependent relaxation in the aorta of rats with experimentally induced type 1 diabetes mellitus, showing that this therapeutical combination may improve and even prevent the vascular complications that occur in diabetic patients. |
| first_indexed | 2024-03-11T03:30:30Z |
| format | Article |
| id | doaj.art-8a72f703fc224a40a8c16248e3519714 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T03:30:30Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-8a72f703fc224a40a8c16248e35197142023-11-18T02:24:58ZengMDPI AGMetabolites2218-19892023-04-0113558610.3390/metabo13050586The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes MellitusIrina-Camelia Chis0Carmen-Maria Micu1Alina Toader2Remus Moldovan3Laura Lele4Simona Clichici5Daniela-Rodica Mitrea6Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Cluj County, RomaniaDepartment of Anatomy and Embryology, Iuliu Hatieganu University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Cluj County, RomaniaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Cluj County, RomaniaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Cluj County, RomaniaDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 10 1 Decembrie Street, 410073 Oradea, Bihor County, RomaniaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Cluj County, RomaniaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 1-3 Clinicilor Street, 400006 Cluj-Napoca, Cluj County, RomaniaType 1 diabetes mellitus is related to the vascular oxidative and nitrosative stress, the trigger for atherosclerosis and cardiovascular complications. The effects of moderate swimming training associated with quercetin oral administration were evaluated in aorta of rats with experimentally induced type 1 diabetes mellitus (T1DM), by analysing the nitric oxide-endothelial dependent relaxation (NO-EDR). T1DM rats received daily quercetin 30 mg/kg and followed the protocol of 5-weeks swimming exercise (30 min/day; 5 days/week). Aorta relaxation to acetylcholine (Ach) and sodium nitroprusside (SNP) were measured at the end of the experiment. Ach-induced endothelial dependent relaxation was significantly decreased in phenylephrine (PE) pre-contracted aorta of diabetic rats. Swimming exercise with quercetin administration preserved Ach-induced EDR but did not have any impact on SNP-induced endothelium-independent relaxation in the diabetic aorta. These findings suggest that quercetin administration associated with moderate swimming exercise could improve the endothelial NO-dependent relaxation in the aorta of rats with experimentally induced type 1 diabetes mellitus, showing that this therapeutical combination may improve and even prevent the vascular complications that occur in diabetic patients.https://www.mdpi.com/2218-1989/13/5/586acetylcholineendotheliumdiabetesquercetinmoderate swimming trainingaorta |
| spellingShingle | Irina-Camelia Chis Carmen-Maria Micu Alina Toader Remus Moldovan Laura Lele Simona Clichici Daniela-Rodica Mitrea The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus Metabolites acetylcholine endothelium diabetes quercetin moderate swimming training aorta |
| title | The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus |
| title_full | The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus |
| title_fullStr | The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus |
| title_full_unstemmed | The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus |
| title_short | The Beneficial Effect of Swimming Training Associated with Quercetin Administration on the Endothelial Nitric Oxide-Dependent Relaxation in the Aorta of Rats with Experimentally Induced Type 1 Diabetes Mellitus |
| title_sort | beneficial effect of swimming training associated with quercetin administration on the endothelial nitric oxide dependent relaxation in the aorta of rats with experimentally induced type 1 diabetes mellitus |
| topic | acetylcholine endothelium diabetes quercetin moderate swimming training aorta |
| url | https://www.mdpi.com/2218-1989/13/5/586 |
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