Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study
BackgroundPrediabetes is associated with increased cardiovascular risk and all-cause mortality, while its regression will decrease the risks. This study investigated the associations of six obesity-related indices (waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CI), body s...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1075225/full |
| _version_ | 1827944291770564608 |
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| author | Hongguang Yang Minjie Zhang Jiaqi Nie Minzhe Zhang Gaolei Lu Rui Chen Qiqiang He Qiqiang He |
| author_facet | Hongguang Yang Minjie Zhang Jiaqi Nie Minzhe Zhang Gaolei Lu Rui Chen Qiqiang He Qiqiang He |
| author_sort | Hongguang Yang |
| collection | DOAJ |
| description | BackgroundPrediabetes is associated with increased cardiovascular risk and all-cause mortality, while its regression will decrease the risks. This study investigated the associations of six obesity-related indices (waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CI), body shape index (ABSI), Chinese visceral adiposity index (CVAI), and triglyceride glucose (TyG) index) with prediabetes regression based on the China Health and Retirement Longitudinal Study (CHARLS), enrolling middle-aged and older adults.MethodsWe included 2,601 participants with prediabetes from CHARLS, who were followed up from 2011–2012 to 2015–2016, with blood samples collected for measuring fasting plasma glucose and hemoglobin A1c. All the obesity-related indices at baseline and their dynamic changes were calculated and categorized into tertiles. Logistic regression analysis was applied to obtain the odds ratio (OR) and 95% confidence intervals (CIs). Attributable fractions (AFs) and 95% CIs of these indices and the dynamic changes were calculated with the AF package in R software, and the cutoff values of initial obesity-related indices were obtained by the receiver operating characteristic (ROC) analysis.ResultsDuring the 4-year follow-up period, 562 (21.61%) participants regressed from prediabetes to normoglycemia. They had lower initial BRI, WHtR, CI, ABSI, CVAI, and TyG than those who did not (P < 0.05). After multivariable adjustment, participants in the first tertile of initial BRI (OR, 1.45, 95%CIs, 1.09–1.93), WHtR (OR, 1.46, 95%CIs, 1.10–1.95), and CVAI (OR, 1.47, 95%CIs, 1.11–1.93) had increased odds of prediabetes regression compared with those in the highest tertile. Participants with decreased TyG (OR, 2.08; 95%CIs, 1.61–2.70) also had increased odds of prediabetes regression compared with those with increased TyG. The cutoff values of initial obesity-related indices were 4.374 for BRI, 0.568 for WHtR, 8.621 for TyG, 1.320 for CI, 0.083 for ABSI, and 106.152 for CVAI, respectively. The AFs were 21.10% for BRI < 4.374, 20.85% for WHtR < 0.568, 17.48% for CVAI < 107.794, and 17.55% for ΔTyG < 0, respectively.ConclusionLow initial BRI, WHtR, and CVAI, as well as TyG reduction, were significantly related to prediabetes regression to normoglycemia, and the AFs were around 20%. Less abdominal fat and insulin resistance reduction would benefit future health outcomes among people with prediabetes. |
| first_indexed | 2024-03-13T10:28:03Z |
| format | Article |
| id | doaj.art-8a739923cfda4fdfbbaf1d413e0c45ce |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T10:28:03Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-8a739923cfda4fdfbbaf1d413e0c45ce2023-05-19T05:16:33ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-05-011010.3389/fnut.2023.10752251075225Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective studyHongguang Yang0Minjie Zhang1Jiaqi Nie2Minzhe Zhang3Gaolei Lu4Rui Chen5Qiqiang He6Qiqiang He7School of Public Health, Wuhan University, Wuhan, ChinaSchool of Public Health, Wuhan University, Wuhan, ChinaSchool of Public Health, Wuhan University, Wuhan, ChinaSchool of Public Health, Wuhan University, Wuhan, ChinaSchool of Public Health, Wuhan University, Wuhan, ChinaSchool of Public Health, Wuhan University, Wuhan, ChinaSchool of Public Health, Wuhan University, Wuhan, ChinaHubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, ChinaBackgroundPrediabetes is associated with increased cardiovascular risk and all-cause mortality, while its regression will decrease the risks. This study investigated the associations of six obesity-related indices (waist-to-height ratio (WHtR), body roundness index (BRI), conicity index (CI), body shape index (ABSI), Chinese visceral adiposity index (CVAI), and triglyceride glucose (TyG) index) with prediabetes regression based on the China Health and Retirement Longitudinal Study (CHARLS), enrolling middle-aged and older adults.MethodsWe included 2,601 participants with prediabetes from CHARLS, who were followed up from 2011–2012 to 2015–2016, with blood samples collected for measuring fasting plasma glucose and hemoglobin A1c. All the obesity-related indices at baseline and their dynamic changes were calculated and categorized into tertiles. Logistic regression analysis was applied to obtain the odds ratio (OR) and 95% confidence intervals (CIs). Attributable fractions (AFs) and 95% CIs of these indices and the dynamic changes were calculated with the AF package in R software, and the cutoff values of initial obesity-related indices were obtained by the receiver operating characteristic (ROC) analysis.ResultsDuring the 4-year follow-up period, 562 (21.61%) participants regressed from prediabetes to normoglycemia. They had lower initial BRI, WHtR, CI, ABSI, CVAI, and TyG than those who did not (P < 0.05). After multivariable adjustment, participants in the first tertile of initial BRI (OR, 1.45, 95%CIs, 1.09–1.93), WHtR (OR, 1.46, 95%CIs, 1.10–1.95), and CVAI (OR, 1.47, 95%CIs, 1.11–1.93) had increased odds of prediabetes regression compared with those in the highest tertile. Participants with decreased TyG (OR, 2.08; 95%CIs, 1.61–2.70) also had increased odds of prediabetes regression compared with those with increased TyG. The cutoff values of initial obesity-related indices were 4.374 for BRI, 0.568 for WHtR, 8.621 for TyG, 1.320 for CI, 0.083 for ABSI, and 106.152 for CVAI, respectively. The AFs were 21.10% for BRI < 4.374, 20.85% for WHtR < 0.568, 17.48% for CVAI < 107.794, and 17.55% for ΔTyG < 0, respectively.ConclusionLow initial BRI, WHtR, and CVAI, as well as TyG reduction, were significantly related to prediabetes regression to normoglycemia, and the AFs were around 20%. Less abdominal fat and insulin resistance reduction would benefit future health outcomes among people with prediabetes.https://www.frontiersin.org/articles/10.3389/fnut.2023.1075225/fullobesityobesity-related indicesprediabetes regressionabdominal fatinsulin resistance |
| spellingShingle | Hongguang Yang Minjie Zhang Jiaqi Nie Minzhe Zhang Gaolei Lu Rui Chen Qiqiang He Qiqiang He Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study Frontiers in Nutrition obesity obesity-related indices prediabetes regression abdominal fat insulin resistance |
| title | Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study |
| title_full | Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study |
| title_fullStr | Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study |
| title_full_unstemmed | Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study |
| title_short | Associations of obesity-related indices with prediabetes regression to normoglycemia among Chinese middle-aged and older adults: a prospective study |
| title_sort | associations of obesity related indices with prediabetes regression to normoglycemia among chinese middle aged and older adults a prospective study |
| topic | obesity obesity-related indices prediabetes regression abdominal fat insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1075225/full |
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