Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations
The search for variants of mitochondrial genome associated with atherosclerosis, in particular, with carotid intima-media thickness (cIMT), is necessary to understand the role of the damage of mitochondrial genome in the development of atherosclerosis. Such data can be useful to provide novel geneti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-04-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920300305 |
| _version_ | 1819171498285334528 |
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| author | Tatiana V. Kirichenko Yulia I. Ragino Mikhail I. Voevoda Saule J. Urazalina Zukhra B. Khasanova Varvara A. Orekhova Vasily V. Sinyov Margarita A. Sazonova Alexander N. Orekhov Igor A. Sobenin |
| author_facet | Tatiana V. Kirichenko Yulia I. Ragino Mikhail I. Voevoda Saule J. Urazalina Zukhra B. Khasanova Varvara A. Orekhova Vasily V. Sinyov Margarita A. Sazonova Alexander N. Orekhov Igor A. Sobenin |
| author_sort | Tatiana V. Kirichenko |
| collection | DOAJ |
| description | The search for variants of mitochondrial genome associated with atherosclerosis, in particular, with carotid intima-media thickness (cIMT), is necessary to understand the role of the damage of mitochondrial genome in the development of atherosclerosis. Such data can be useful to provide novel genetic markers of predisposition to atherosclerosis and molecular targets for further development of technologies aimed to prevent age-related degenerative pathologies. Data presented in this article demonstrate the association of several heteroplasmic variants of mitochondrial DNA (mtDNA) previously described as proatherogenic ones with cIMT in 251 participants (190 participants from Novosibirsk, Russia, and 61 participant from Almaty, Kazakhstan). It was shown that the occurrence of some variants of mitochondrial genome is different in samples derived from Russian and Kazakh populations; the level of mitochondrial heteroplasmy m.13513G > A correlates negatively with mean cIMT in both Russian and Kazakh participants. Keywords: Mitochondrial mutations, Heteroplasmy, Carotid atherosclerosis, Intima-media thickness, Cardiovascular risk factors |
| first_indexed | 2024-12-22T19:52:15Z |
| format | Article |
| id | doaj.art-8a793a461870495f8c83bdc2f2ce0abe |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-22T19:52:15Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-8a793a461870495f8c83bdc2f2ce0abe2022-12-21T18:14:31ZengElsevierData in Brief2352-34092020-04-0129Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populationsTatiana V. Kirichenko0Yulia I. Ragino1Mikhail I. Voevoda2Saule J. Urazalina3Zukhra B. Khasanova4Varvara A. Orekhova5Vasily V. Sinyov6Margarita A. Sazonova7Alexander N. Orekhov8Igor A. Sobenin9Research Institute of Human Morphology, Moscow, Russia; National Medical Research Center of Cardiology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia; Corresponding author. Research Institute of Human Morphology, 3 Tsyurupa Str., 117418, Moscow, Russia.Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, RussiaFederal Research Center of Fundamental and Translational Medicine, Novosibirsk, RussiaJSK Scientific-Research Institute of Cardiology and Internal Diseases, Almaty, KazakhstanNational Medical Research Center of Cardiology, Moscow, RussiaNational Medical Research Center of Cardiology, Moscow, RussiaNational Medical Research Center of Cardiology, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, RussiaNational Medical Research Center of Cardiology, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, RussiaResearch Institute of Human Morphology, Moscow, Russia; Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, RussiaResearch Institute of Human Morphology, Moscow, Russia; National Medical Research Center of Cardiology, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, RussiaThe search for variants of mitochondrial genome associated with atherosclerosis, in particular, with carotid intima-media thickness (cIMT), is necessary to understand the role of the damage of mitochondrial genome in the development of atherosclerosis. Such data can be useful to provide novel genetic markers of predisposition to atherosclerosis and molecular targets for further development of technologies aimed to prevent age-related degenerative pathologies. Data presented in this article demonstrate the association of several heteroplasmic variants of mitochondrial DNA (mtDNA) previously described as proatherogenic ones with cIMT in 251 participants (190 participants from Novosibirsk, Russia, and 61 participant from Almaty, Kazakhstan). It was shown that the occurrence of some variants of mitochondrial genome is different in samples derived from Russian and Kazakh populations; the level of mitochondrial heteroplasmy m.13513G > A correlates negatively with mean cIMT in both Russian and Kazakh participants. Keywords: Mitochondrial mutations, Heteroplasmy, Carotid atherosclerosis, Intima-media thickness, Cardiovascular risk factorshttp://www.sciencedirect.com/science/article/pii/S2352340920300305 |
| spellingShingle | Tatiana V. Kirichenko Yulia I. Ragino Mikhail I. Voevoda Saule J. Urazalina Zukhra B. Khasanova Varvara A. Orekhova Vasily V. Sinyov Margarita A. Sazonova Alexander N. Orekhov Igor A. Sobenin Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations Data in Brief |
| title | Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations |
| title_full | Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations |
| title_fullStr | Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations |
| title_full_unstemmed | Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations |
| title_short | Data on association of mitochondrial heteroplasmy with carotid intima-media thickness in subjects from Russian and Kazakh populations |
| title_sort | data on association of mitochondrial heteroplasmy with carotid intima media thickness in subjects from russian and kazakh populations |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920300305 |
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