Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors
Background: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few...
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/14/3295 |
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| author | Orsolya Juhász Noémi Jákob Hajnalka Rajnai Marcell Imrei Miklós Garami |
| author_facet | Orsolya Juhász Noémi Jákob Hajnalka Rajnai Marcell Imrei Miklós Garami |
| author_sort | Orsolya Juhász |
| collection | DOAJ |
| description | Background: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few studies. Methods: For this study, 177 children with solid tumors were selected whose biopsies and tumor tissue formalin-fixed, paraffin-embedded tissue blocks were available for immunohistochemical analysis at Semmelweis University, Budapest (Hungary). Results: We found that non-significant VDR expression was associated with a significantly less favorable prognosis (<i>p</i> = 0.0061) in the examined childhood solid tumors. There was a clinically significant association; non-significant VDR expression had more than 14-fold odds of an unfavorable prognosis (OR = 14.74). The rate of VDR expression differed significantly between tumor types (<i>p</i> < 0.0001). Conclusion: In conclusion, VDR expression measured by IHC staining is inversely associated with aggressive characteristics in different childhood cancers. The downregulation of VDR expression in more aggressive childhood cancers suggests that functional vitamin D activity may slow or block cancer progression. |
| first_indexed | 2024-03-09T12:07:48Z |
| format | Article |
| id | doaj.art-8a7a3f2caaac4614adba2827fa7612d8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:07:48Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8a7a3f2caaac4614adba2827fa7612d82023-11-30T22:55:35ZengMDPI AGCancers2072-66942022-07-011414329510.3390/cancers14143295Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid TumorsOrsolya Juhász0Noémi Jákob1Hajnalka Rajnai2Marcell Imrei3Miklós Garami42nd Department of Pediatrics, Semmelweis University, 1094 Budapest, Hungary1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, Hungary1st Department of Pathology and Experimental Cancer Research, Semmelweis University, 1085 Budapest, HungaryCentre for Translational Medicine, Semmelweis University, 1085 Budapest, Hungary2nd Department of Pediatrics, Semmelweis University, 1094 Budapest, HungaryBackground: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few studies. Methods: For this study, 177 children with solid tumors were selected whose biopsies and tumor tissue formalin-fixed, paraffin-embedded tissue blocks were available for immunohistochemical analysis at Semmelweis University, Budapest (Hungary). Results: We found that non-significant VDR expression was associated with a significantly less favorable prognosis (<i>p</i> = 0.0061) in the examined childhood solid tumors. There was a clinically significant association; non-significant VDR expression had more than 14-fold odds of an unfavorable prognosis (OR = 14.74). The rate of VDR expression differed significantly between tumor types (<i>p</i> < 0.0001). Conclusion: In conclusion, VDR expression measured by IHC staining is inversely associated with aggressive characteristics in different childhood cancers. The downregulation of VDR expression in more aggressive childhood cancers suggests that functional vitamin D activity may slow or block cancer progression.https://www.mdpi.com/2072-6694/14/14/3295vitamin D receptorchildhood cancerstissue microarraysurvival |
| spellingShingle | Orsolya Juhász Noémi Jákob Hajnalka Rajnai Marcell Imrei Miklós Garami Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors Cancers vitamin D receptor childhood cancers tissue microarray survival |
| title | Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors |
| title_full | Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors |
| title_fullStr | Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors |
| title_full_unstemmed | Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors |
| title_short | Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors |
| title_sort | immunohistochemical detection of the presence of vitamin d receptor in childhood solid tumors |
| topic | vitamin D receptor childhood cancers tissue microarray survival |
| url | https://www.mdpi.com/2072-6694/14/14/3295 |
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