Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells
Infertility and menstrual abnormalities in endometriosis patients are frequently caused by aberrant follicular growth or a reduced ovarian reserve. Endometriosis typically does not directly harm the oocyte, but rather inhibits the function of granulosa cells, resulting in a decrease in oocyte qualit...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1226687/full |
| _version_ | 1797741695766364160 |
|---|---|
| author | Weisen Fan Zheng Yuan Muzhen Li Yingjie Zhang Fengjuan Nan |
| author_facet | Weisen Fan Zheng Yuan Muzhen Li Yingjie Zhang Fengjuan Nan |
| author_sort | Weisen Fan |
| collection | DOAJ |
| description | Infertility and menstrual abnormalities in endometriosis patients are frequently caused by aberrant follicular growth or a reduced ovarian reserve. Endometriosis typically does not directly harm the oocyte, but rather inhibits the function of granulosa cells, resulting in a decrease in oocyte quality. Granulosa cells, as oocyte nanny cells, can regulate meiosis, provide the most basic resources required for oocyte development, and influence ovulation. Endometriosis affects oocyte development and quality by causing granulosa cells apoptosis, inflammation, oxidative stress, steroid synthesis obstacle, and aberrant mitochondrial energy metabolism. These aberrant states frequently interact with one another, however there is currently relatively little research in this field to understand the mechanism of linkage between abnormal states. |
| first_indexed | 2024-03-12T14:30:25Z |
| format | Article |
| id | doaj.art-8a7a7172d35944d8aed939fad2b7dd75 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T14:30:25Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8a7a7172d35944d8aed939fad2b7dd752023-08-17T13:35:33ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12266871226687Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cellsWeisen Fan0Zheng Yuan1Muzhen Li2Yingjie Zhang3Fengjuan Nan4The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaCollege of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Gynecology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaInfertility and menstrual abnormalities in endometriosis patients are frequently caused by aberrant follicular growth or a reduced ovarian reserve. Endometriosis typically does not directly harm the oocyte, but rather inhibits the function of granulosa cells, resulting in a decrease in oocyte quality. Granulosa cells, as oocyte nanny cells, can regulate meiosis, provide the most basic resources required for oocyte development, and influence ovulation. Endometriosis affects oocyte development and quality by causing granulosa cells apoptosis, inflammation, oxidative stress, steroid synthesis obstacle, and aberrant mitochondrial energy metabolism. These aberrant states frequently interact with one another, however there is currently relatively little research in this field to understand the mechanism of linkage between abnormal states.https://www.frontiersin.org/articles/10.3389/fendo.2023.1226687/fullendometriosisgranulosa cellsinfertilitymechanismoocytes |
| spellingShingle | Weisen Fan Zheng Yuan Muzhen Li Yingjie Zhang Fengjuan Nan Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells Frontiers in Endocrinology endometriosis granulosa cells infertility mechanism oocytes |
| title | Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells |
| title_full | Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells |
| title_fullStr | Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells |
| title_full_unstemmed | Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells |
| title_short | Decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells |
| title_sort | decreased oocyte quality in patients with endometriosis is closely related to abnormal granulosa cells |
| topic | endometriosis granulosa cells infertility mechanism oocytes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1226687/full |
| work_keys_str_mv | AT weisenfan decreasedoocytequalityinpatientswithendometriosisiscloselyrelatedtoabnormalgranulosacells AT zhengyuan decreasedoocytequalityinpatientswithendometriosisiscloselyrelatedtoabnormalgranulosacells AT muzhenli decreasedoocytequalityinpatientswithendometriosisiscloselyrelatedtoabnormalgranulosacells AT yingjiezhang decreasedoocytequalityinpatientswithendometriosisiscloselyrelatedtoabnormalgranulosacells AT fengjuannan decreasedoocytequalityinpatientswithendometriosisiscloselyrelatedtoabnormalgranulosacells |