Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia.
Enterovirus 71 (EV71) is an emerging human pathogen causing massive epidemics of hand, foot and mouth disease with severe neurological complications in Asia. EV71 also circulates in Europe, however it does not cause large outbreaks. The reason for distinct epidemiological patterns of EV71 infection...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4018281?pdf=render |
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| author | Ludmila V Akhmadishina Tatiana P Eremeeva Olga E Trotsenko Olga E Ivanova Mikhail I Mikhailov Alexander N Lukashev |
| author_facet | Ludmila V Akhmadishina Tatiana P Eremeeva Olga E Trotsenko Olga E Ivanova Mikhail I Mikhailov Alexander N Lukashev |
| author_sort | Ludmila V Akhmadishina |
| collection | DOAJ |
| description | Enterovirus 71 (EV71) is an emerging human pathogen causing massive epidemics of hand, foot and mouth disease with severe neurological complications in Asia. EV71 also circulates in Europe, however it does not cause large outbreaks. The reason for distinct epidemiological patterns of EV71 infection in Europe and Asia and the risk of EV71 epidemic in Europe and Russia remain unknown. Seroepidemiology of EV71 and molecular epidemiology of occasional EV71 isolates were studied to explore circulation of EV71 in Russia. In six regions of Russian Federation, seroprevalence of EV71 in sera collected in 2008 ranged from 5% to 20% in children aged 1-2 years and from 19% to 83% in children aged 3-5 years. The seroprevalence among elder children was significantly higher (41-83% vs. 19-27%) in Asian regions of Russia. EV71 strains identified in Russia in 2001-2011 belonged to subtypes C1 and C2, while genotype C4 that was causing epidemics in Asia since 1998 emerged in 2009 and became dominant in 2013. |
| first_indexed | 2024-12-16T16:27:58Z |
| format | Article |
| id | doaj.art-8a7aa3abc8f24f4f8140db9707d4b7c2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T16:27:58Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8a7aa3abc8f24f4f8140db9707d4b7c22022-12-21T22:24:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9740410.1371/journal.pone.0097404Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia.Ludmila V AkhmadishinaTatiana P EremeevaOlga E TrotsenkoOlga E IvanovaMikhail I MikhailovAlexander N LukashevEnterovirus 71 (EV71) is an emerging human pathogen causing massive epidemics of hand, foot and mouth disease with severe neurological complications in Asia. EV71 also circulates in Europe, however it does not cause large outbreaks. The reason for distinct epidemiological patterns of EV71 infection in Europe and Asia and the risk of EV71 epidemic in Europe and Russia remain unknown. Seroepidemiology of EV71 and molecular epidemiology of occasional EV71 isolates were studied to explore circulation of EV71 in Russia. In six regions of Russian Federation, seroprevalence of EV71 in sera collected in 2008 ranged from 5% to 20% in children aged 1-2 years and from 19% to 83% in children aged 3-5 years. The seroprevalence among elder children was significantly higher (41-83% vs. 19-27%) in Asian regions of Russia. EV71 strains identified in Russia in 2001-2011 belonged to subtypes C1 and C2, while genotype C4 that was causing epidemics in Asia since 1998 emerged in 2009 and became dominant in 2013.http://europepmc.org/articles/PMC4018281?pdf=render |
| spellingShingle | Ludmila V Akhmadishina Tatiana P Eremeeva Olga E Trotsenko Olga E Ivanova Mikhail I Mikhailov Alexander N Lukashev Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. PLoS ONE |
| title | Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. |
| title_full | Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. |
| title_fullStr | Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. |
| title_full_unstemmed | Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. |
| title_short | Seroepidemiology and molecular epidemiology of enterovirus 71 in Russia. |
| title_sort | seroepidemiology and molecular epidemiology of enterovirus 71 in russia |
| url | http://europepmc.org/articles/PMC4018281?pdf=render |
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