The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment
Periodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.896745/full |
| _version_ | 1811258000105537536 |
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| author | Zeyu Zhang Zeyu Zhang Yang Yu Guanxiong Zhu Guanxiong Zhu Liting Zeng Liting Zeng Shaofen Xu Shaofen Xu Haoyu Cheng Haoyu Cheng Zhaoguang Ouyang Zhaoguang Ouyang Jianwei Chen Jianwei Chen Janak L. Pathak Lihong Wu Lihong Wu Lina Yu Lina Yu |
| author_facet | Zeyu Zhang Zeyu Zhang Yang Yu Guanxiong Zhu Guanxiong Zhu Liting Zeng Liting Zeng Shaofen Xu Shaofen Xu Haoyu Cheng Haoyu Cheng Zhaoguang Ouyang Zhaoguang Ouyang Jianwei Chen Jianwei Chen Janak L. Pathak Lihong Wu Lihong Wu Lina Yu Lina Yu |
| author_sort | Zeyu Zhang |
| collection | DOAJ |
| description | Periodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, it is urgent to explore new therapeutic strategies for periodontitis. Natural products show anti-microbial, anti-inflammatory, anti-oxidant and bone protective effects to periodontitis and most of these natural products are safe and cost-effective. Among these, the plant-derived exosome-like nanoparticles (PELNs), a type of natural nanocarriers repleted with lipids, proteins, RNAs, and other active molecules, show the ability to enter mammalian cells and regulate cellular activities. Reports from the literature indicate the great potential of PELNs in the regulation of immune functions, inflammation, microbiome, and tissue regeneration. Moreover, PELNs can also be used as drug carriers to enhance drug stability and cellular uptake in vivo. Since regulation of immune function, inflammation, microbiome, and tissue regeneration are the key phenomena usually targeted during periodontitis treatment, the PELNs hold the promising potential for periodontitis treatment. This review summarizes the recent advances in PELNs-related research that are related to the treatment of periodontitis and regeneration of periodontitis-destructed tissues and the underlying mechanisms. We also discuss the existing challenges and prospects of the application of PELNs-based therapeutic approaches for periodontitis treatment. |
| first_indexed | 2024-04-12T18:06:23Z |
| format | Article |
| id | doaj.art-8a7ded0aa92f4a93bf93bb75c224c362 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T18:06:23Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8a7ded0aa92f4a93bf93bb75c224c3622022-12-22T03:21:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-06-011310.3389/fimmu.2022.896745896745The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis TreatmentZeyu Zhang0Zeyu Zhang1Yang Yu2Guanxiong Zhu3Guanxiong Zhu4Liting Zeng5Liting Zeng6Shaofen Xu7Shaofen Xu8Haoyu Cheng9Haoyu Cheng10Zhaoguang Ouyang11Zhaoguang Ouyang12Jianwei Chen13Jianwei Chen14Janak L. Pathak15Lihong Wu16Lihong Wu17Lina Yu18Lina Yu19Department of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Sports and Health, Guangzhou Sport University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaDepartment of Preventive Dentistry, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, ChinaSchool and Hospital of Stomatology, Guangzhou Medical University, Guangzhou, ChinaPeriodontitis is an infectious oral disease, which leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, it is urgent to explore new therapeutic strategies for periodontitis. Natural products show anti-microbial, anti-inflammatory, anti-oxidant and bone protective effects to periodontitis and most of these natural products are safe and cost-effective. Among these, the plant-derived exosome-like nanoparticles (PELNs), a type of natural nanocarriers repleted with lipids, proteins, RNAs, and other active molecules, show the ability to enter mammalian cells and regulate cellular activities. Reports from the literature indicate the great potential of PELNs in the regulation of immune functions, inflammation, microbiome, and tissue regeneration. Moreover, PELNs can also be used as drug carriers to enhance drug stability and cellular uptake in vivo. Since regulation of immune function, inflammation, microbiome, and tissue regeneration are the key phenomena usually targeted during periodontitis treatment, the PELNs hold the promising potential for periodontitis treatment. This review summarizes the recent advances in PELNs-related research that are related to the treatment of periodontitis and regeneration of periodontitis-destructed tissues and the underlying mechanisms. We also discuss the existing challenges and prospects of the application of PELNs-based therapeutic approaches for periodontitis treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2022.896745/fullplant-derived exosome-like nanoparticlesperiodontitisexosomesinflammationoral tissue regenerationdrug delivery systems |
| spellingShingle | Zeyu Zhang Zeyu Zhang Yang Yu Guanxiong Zhu Guanxiong Zhu Liting Zeng Liting Zeng Shaofen Xu Shaofen Xu Haoyu Cheng Haoyu Cheng Zhaoguang Ouyang Zhaoguang Ouyang Jianwei Chen Jianwei Chen Janak L. Pathak Lihong Wu Lihong Wu Lina Yu Lina Yu The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment Frontiers in Immunology plant-derived exosome-like nanoparticles periodontitis exosomes inflammation oral tissue regeneration drug delivery systems |
| title | The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment |
| title_full | The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment |
| title_fullStr | The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment |
| title_full_unstemmed | The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment |
| title_short | The Emerging Role of Plant-Derived Exosomes-Like Nanoparticles in Immune Regulation and Periodontitis Treatment |
| title_sort | emerging role of plant derived exosomes like nanoparticles in immune regulation and periodontitis treatment |
| topic | plant-derived exosome-like nanoparticles periodontitis exosomes inflammation oral tissue regeneration drug delivery systems |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.896745/full |
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