Paeoniflorin Ameliorates Chronic Stress-Induced Depression-Like Behaviors and Neuronal Damages in Rats via Activation of the ERK-CREB Pathway

Paeoniflorin Ameliorates Chronic Stress-Induced Depression-Like Behaviors and Neuronal Damages in Rats via Activation of the ERK-CREB Pathway

Neuronal damage is related to the onset and treatment of depressive disorders. Antidepressant-like effects have been elicited by paeoniflorin on animal models. The aim of this study is to demonstrate whether the neuroprotective effect of paeoniflorin on rats suffered from chronic unpredictable mild...

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Bibliographic Details
Main Authors: Xiaoming Zhong, Guanze Li, Fengmei Qiu, Zhen Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Psychiatry
Subjects:
neuroprotection
paeoniflorin
chronic mild stress
ERK-CREB pathway
U0126
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00772/full

Internet

https://www.frontiersin.org/article/10.3389/fpsyt.2018.00772/full

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