Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer
Exosomes are composed of a lipid bilayer membrane, containing proteins, nucleic acids, DNA, RNA, etc., derived from donor cells. They have a size range of approximately 30-150 nm. The intrinsic characteristics of exosomes, including efficient cellular uptake, low immunogenicity, low toxicity, intrin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.743189/full |
| _version_ | 1818722541928185856 |
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| author | Yuying Zhao Yuying Zhao Piaoxue Liu Hanxu Tan Xiaojia Chen Qi Wang Tongkai Chen |
| author_facet | Yuying Zhao Yuying Zhao Piaoxue Liu Hanxu Tan Xiaojia Chen Qi Wang Tongkai Chen |
| author_sort | Yuying Zhao |
| collection | DOAJ |
| description | Exosomes are composed of a lipid bilayer membrane, containing proteins, nucleic acids, DNA, RNA, etc., derived from donor cells. They have a size range of approximately 30-150 nm. The intrinsic characteristics of exosomes, including efficient cellular uptake, low immunogenicity, low toxicity, intrinsic ability to traverse biological barriers, and inherent targeting ability, facilitate their application to the drug delivery system. Here, we review the generation, uptake, separation, and purification methods of exosomes, focusing on their application as carriers in tumor diagnosis and treatment, especially in brain tumors, as well as the patent applications of exosomes in recent years. |
| first_indexed | 2024-12-17T20:56:16Z |
| format | Article |
| id | doaj.art-8a82e2e45be845b386ff388601ee7321 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T20:56:16Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8a82e2e45be845b386ff388601ee73212022-12-21T21:32:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.743189743189Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of CancerYuying Zhao0Yuying Zhao1Piaoxue Liu2Hanxu Tan3Xiaojia Chen4Qi Wang5Tongkai Chen6Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Collage of Guangzhou University of Chinese Medicine, Guangzhou, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Fundamental Medical Science, Guangzhou University of Chinese Medicine, Guangzhou, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, ChinaExosomes are composed of a lipid bilayer membrane, containing proteins, nucleic acids, DNA, RNA, etc., derived from donor cells. They have a size range of approximately 30-150 nm. The intrinsic characteristics of exosomes, including efficient cellular uptake, low immunogenicity, low toxicity, intrinsic ability to traverse biological barriers, and inherent targeting ability, facilitate their application to the drug delivery system. Here, we review the generation, uptake, separation, and purification methods of exosomes, focusing on their application as carriers in tumor diagnosis and treatment, especially in brain tumors, as well as the patent applications of exosomes in recent years.https://www.frontiersin.org/articles/10.3389/fonc.2021.743189/fullexosomesbiomarkercancer diagnosiscancer therapybrain cancer |
| spellingShingle | Yuying Zhao Yuying Zhao Piaoxue Liu Hanxu Tan Xiaojia Chen Qi Wang Tongkai Chen Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer Frontiers in Oncology exosomes biomarker cancer diagnosis cancer therapy brain cancer |
| title | Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer |
| title_full | Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer |
| title_fullStr | Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer |
| title_full_unstemmed | Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer |
| title_short | Exosomes as Smart Nanoplatforms for Diagnosis and Therapy of Cancer |
| title_sort | exosomes as smart nanoplatforms for diagnosis and therapy of cancer |
| topic | exosomes biomarker cancer diagnosis cancer therapy brain cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.743189/full |
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