An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome
Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/1/109 |
| _version_ | 1797358605814464512 |
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| author | Mateusz Matwiejuk Hanna Myśliwiec Adrian Chabowski Iwona Flisiak |
| author_facet | Mateusz Matwiejuk Hanna Myśliwiec Adrian Chabowski Iwona Flisiak |
| author_sort | Mateusz Matwiejuk |
| collection | DOAJ |
| description | Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In particular, the potential link between psoriasis and metabolic syndrome is an issue worthy of attention. The dysregulation of growth factors could potentially contribute to the disturbances of keratinocyte proliferation, inflammation, and itch severity. However, the pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome, remains incompletely elucidated. Growth factors and their abnormal metabolism may be a potential link connecting these conditions. Overall, the objective of this review is to analyze the role of growth factor disturbances in both psoriasis and metabolic syndrome. |
| first_indexed | 2024-03-08T15:04:13Z |
| format | Article |
| id | doaj.art-8a83f035d4004fa5af0862f23d304eca |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T15:04:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8a83f035d4004fa5af0862f23d304eca2024-01-10T15:01:06ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-0113110910.3390/jcm13010109An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic SyndromeMateusz Matwiejuk0Hanna Myśliwiec1Adrian Chabowski2Iwona Flisiak3Department of Dermatology and Venereology, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Physiology, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Dermatology and Venereology, Medical University of Bialystok, 15-089 Bialystok, PolandPsoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In particular, the potential link between psoriasis and metabolic syndrome is an issue worthy of attention. The dysregulation of growth factors could potentially contribute to the disturbances of keratinocyte proliferation, inflammation, and itch severity. However, the pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome, remains incompletely elucidated. Growth factors and their abnormal metabolism may be a potential link connecting these conditions. Overall, the objective of this review is to analyze the role of growth factor disturbances in both psoriasis and metabolic syndrome.https://www.mdpi.com/2077-0383/13/1/109bFGFHGFNGF bSCFPDGF-BBM-CSF |
| spellingShingle | Mateusz Matwiejuk Hanna Myśliwiec Adrian Chabowski Iwona Flisiak An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome Journal of Clinical Medicine bFGF HGF NGF b SCF PDGF-BB M-CSF |
| title | An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome |
| title_full | An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome |
| title_fullStr | An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome |
| title_full_unstemmed | An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome |
| title_short | An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome |
| title_sort | overview of growth factors as the potential link between psoriasis and metabolic syndrome |
| topic | bFGF HGF NGF b SCF PDGF-BB M-CSF |
| url | https://www.mdpi.com/2077-0383/13/1/109 |
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