"Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria "
Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-β1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2006-09-01
|
| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/142 |
| _version_ | 1818392748933251072 |
|---|---|
| author | Sara Hosseini-Farahabadi Jalil Tavakkol-Afshari Rashin Ganjali Houshang Rafatpanah Javad Ghaffari Reza Farid-Hosseini |
| author_facet | Sara Hosseini-Farahabadi Jalil Tavakkol-Afshari Rashin Ganjali Houshang Rafatpanah Javad Ghaffari Reza Farid-Hosseini |
| author_sort | Sara Hosseini-Farahabadi |
| collection | DOAJ |
| description | Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-β1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat.
A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-β1 promoter –509C>T polymorphism was determined by PCR-RFLP method.
Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele.
These results do suggest an influence of genetic variability at the promoter of TGF-β1 gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful genetic change in our study. Further work is required to confirm this result. |
| first_indexed | 2024-12-14T05:34:21Z |
| format | Article |
| id | doaj.art-8a8439065809433a962ab06937b1b395 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-14T05:34:21Z |
| publishDate | 2006-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-8a8439065809433a962ab06937b1b3952022-12-21T23:15:14ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492006-09-0153142"Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " Sara Hosseini-Farahabadi0 Jalil Tavakkol-Afshari1 Rashin Ganjali2 Houshang Rafatpanah3 Javad Ghaffari4 Reza Farid-Hosseini5 Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism of TGF-β1 gene may be involved in ICU. This condition is thought to affect at least 0.1% of the population and often can be severe and difficult to treat. A total of 40 patients with ICU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-β1 promoter –509C>T polymorphism was determined by PCR-RFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 26 (65%) had CT and 3 (7.5%) had TT genotypes. A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of genetic variability at the promoter of TGF-β1 gene (-509C>T) on the occurrence of ICU. This polymorphism has been shown as a useful genetic change in our study. Further work is required to confirm this result.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/142TGF-β1 geneUrticaria |
| spellingShingle | Sara Hosseini-Farahabadi Jalil Tavakkol-Afshari Rashin Ganjali Houshang Rafatpanah Javad Ghaffari Reza Farid-Hosseini "Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " Iranian Journal of Allergy, Asthma and Immunology TGF-β1 gene Urticaria |
| title | "Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " |
| title_full | "Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " |
| title_fullStr | "Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " |
| title_full_unstemmed | "Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " |
| title_short | "Association between the Polymorphism of TGF-β1 Gene Promoter (-509C>T) and Idiopathic Chronic Urticaria " |
| title_sort | association between the polymorphism of tgf β1 gene promoter 509c t and idiopathic chronic urticaria |
| topic | TGF-β1 gene Urticaria |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/142 |
| work_keys_str_mv | AT sarahosseinifarahabadi associationbetweenthepolymorphismoftgfb1genepromoter509ctandidiopathicchronicurticaria AT jaliltavakkolafshari associationbetweenthepolymorphismoftgfb1genepromoter509ctandidiopathicchronicurticaria AT rashinganjali associationbetweenthepolymorphismoftgfb1genepromoter509ctandidiopathicchronicurticaria AT houshangrafatpanah associationbetweenthepolymorphismoftgfb1genepromoter509ctandidiopathicchronicurticaria AT javadghaffari associationbetweenthepolymorphismoftgfb1genepromoter509ctandidiopathicchronicurticaria AT rezafaridhosseini associationbetweenthepolymorphismoftgfb1genepromoter509ctandidiopathicchronicurticaria |