Applications of human organoids in the personalized treatment for digestive diseases
Abstract Digestive system diseases arise primarily through the interplay of genetic and environmental influences; there is an urgent need in elucidating the pathogenic mechanisms of these diseases and deploy personalized treatments. Traditional and long-established model systems rarely reproduce eit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-09-01
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| Series: | Signal Transduction and Targeted Therapy |
| Online Access: | https://doi.org/10.1038/s41392-022-01194-6 |
| _version_ | 1811201142106882048 |
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| author | Qinying Wang Fanying Guo Yutao Jin Yanlei Ma |
| author_facet | Qinying Wang Fanying Guo Yutao Jin Yanlei Ma |
| author_sort | Qinying Wang |
| collection | DOAJ |
| description | Abstract Digestive system diseases arise primarily through the interplay of genetic and environmental influences; there is an urgent need in elucidating the pathogenic mechanisms of these diseases and deploy personalized treatments. Traditional and long-established model systems rarely reproduce either tissue complexity or human physiology faithfully; these shortcomings underscore the need for better models. Organoids represent a promising research model, helping us gain a more profound understanding of the digestive organs; this model can also be used to provide patients with precise and individualized treatment and to build rapid in vitro test models for drug screening or gene/cell therapy, linking basic research with clinical treatment. Over the past few decades, the use of organoids has led to an advanced understanding of the composition of each digestive organ and has facilitated disease modeling, chemotherapy dose prediction, CRISPR-Cas9 genetic intervention, high-throughput drug screening, and identification of SARS-CoV-2 targets, pathogenic infection. However, the existing organoids of the digestive system mainly include the epithelial system. In order to reveal the pathogenic mechanism of digestive diseases, it is necessary to establish a completer and more physiological organoid model. Combining organoids and advanced techniques to test individualized treatments of different formulations is a promising approach that requires further exploration. This review highlights the advancements in the field of organoid technology from the perspectives of disease modeling and personalized therapy. |
| first_indexed | 2024-04-12T02:15:50Z |
| format | Article |
| id | doaj.art-8a8452f5f31f40dd8cfb72d117b1a229 |
| institution | Directory Open Access Journal |
| issn | 2059-3635 |
| language | English |
| last_indexed | 2024-04-12T02:15:50Z |
| publishDate | 2022-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Signal Transduction and Targeted Therapy |
| spelling | doaj.art-8a8452f5f31f40dd8cfb72d117b1a2292022-12-22T03:52:15ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352022-09-017113010.1038/s41392-022-01194-6Applications of human organoids in the personalized treatment for digestive diseasesQinying Wang0Fanying Guo1Yutao Jin2Yanlei Ma3Department of Colorectal Surgery, Fudan University Shanghai Cancer CenterSchool of Clinical Medicine, Shanghai Medical College, Fudan UniversityDepartment of Colorectal Surgery, Fudan University Shanghai Cancer CenterDepartment of Colorectal Surgery, Fudan University Shanghai Cancer CenterAbstract Digestive system diseases arise primarily through the interplay of genetic and environmental influences; there is an urgent need in elucidating the pathogenic mechanisms of these diseases and deploy personalized treatments. Traditional and long-established model systems rarely reproduce either tissue complexity or human physiology faithfully; these shortcomings underscore the need for better models. Organoids represent a promising research model, helping us gain a more profound understanding of the digestive organs; this model can also be used to provide patients with precise and individualized treatment and to build rapid in vitro test models for drug screening or gene/cell therapy, linking basic research with clinical treatment. Over the past few decades, the use of organoids has led to an advanced understanding of the composition of each digestive organ and has facilitated disease modeling, chemotherapy dose prediction, CRISPR-Cas9 genetic intervention, high-throughput drug screening, and identification of SARS-CoV-2 targets, pathogenic infection. However, the existing organoids of the digestive system mainly include the epithelial system. In order to reveal the pathogenic mechanism of digestive diseases, it is necessary to establish a completer and more physiological organoid model. Combining organoids and advanced techniques to test individualized treatments of different formulations is a promising approach that requires further exploration. This review highlights the advancements in the field of organoid technology from the perspectives of disease modeling and personalized therapy.https://doi.org/10.1038/s41392-022-01194-6 |
| spellingShingle | Qinying Wang Fanying Guo Yutao Jin Yanlei Ma Applications of human organoids in the personalized treatment for digestive diseases Signal Transduction and Targeted Therapy |
| title | Applications of human organoids in the personalized treatment for digestive diseases |
| title_full | Applications of human organoids in the personalized treatment for digestive diseases |
| title_fullStr | Applications of human organoids in the personalized treatment for digestive diseases |
| title_full_unstemmed | Applications of human organoids in the personalized treatment for digestive diseases |
| title_short | Applications of human organoids in the personalized treatment for digestive diseases |
| title_sort | applications of human organoids in the personalized treatment for digestive diseases |
| url | https://doi.org/10.1038/s41392-022-01194-6 |
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