Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment
Previous studies have shown that the structural and functional impairments of hippocampal subregions in patients with obstructive sleep apnea (OSA) are related to cognitive impairment. Continuous positive airway pressure (CPAP) treatment can improve the clinical symptoms of OSA. Therefore, this stud...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/5/838 |
| _version_ | 1797600785719099392 |
|---|---|
| author | Ling Huang Haijun Li Yongqiang Shu Kunyao Li Wei Xie Yaping Zeng Ting Long Li Zeng Xiang Liu Dechang Peng |
| author_facet | Ling Huang Haijun Li Yongqiang Shu Kunyao Li Wei Xie Yaping Zeng Ting Long Li Zeng Xiang Liu Dechang Peng |
| author_sort | Ling Huang |
| collection | DOAJ |
| description | Previous studies have shown that the structural and functional impairments of hippocampal subregions in patients with obstructive sleep apnea (OSA) are related to cognitive impairment. Continuous positive airway pressure (CPAP) treatment can improve the clinical symptoms of OSA. Therefore, this study aimed to investigate functional connectivity (FC) changes in hippocampal subregions of patients with OSA after six months of CPAP treatment (post-CPAP) and its relationship with neurocognitive function. We collected and analyzed baseline (pre-CPAP) and post-CPAP data from 20 patients with OSA, including sleep monitoring, clinical evaluation, and resting-state functional magnetic resonance imaging. The results showed that compared with pre-CPAP OSA patients, the FC between the right anterior hippocampal gyrus and multiple brain regions, and between the left anterior hippocampal gyrus and posterior central gyrus were reduced in post-CPAP OSA patients. By contrast, the FC between the left middle hippocampus and the left precentral gyrus was increased. The changes in FC in these brain regions were closely related to cognitive dysfunction. Therefore, our findings suggest that CPAP treatment can effectively change the FC patterns of hippocampal subregions in patients with OSA, facilitating a better understanding of the neural mechanisms of cognitive function improvement, and emphasizing the importance of early diagnosis and timely treatment of OSA. |
| first_indexed | 2024-03-11T03:53:52Z |
| format | Article |
| id | doaj.art-8a84a65cdf074846bfec4e79ad0dac1b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T03:53:52Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-8a84a65cdf074846bfec4e79ad0dac1b2023-11-18T00:43:35ZengMDPI AGBrain Sciences2076-34252023-05-0113583810.3390/brainsci13050838Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure TreatmentLing Huang0Haijun Li1Yongqiang Shu2Kunyao Li3Wei Xie4Yaping Zeng5Ting Long6Li Zeng7Xiang Liu8Dechang Peng9Medical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaMedical Imaging Center, The First Affiliated Hospital of Nanchang University, Nanchang 330000, ChinaPrevious studies have shown that the structural and functional impairments of hippocampal subregions in patients with obstructive sleep apnea (OSA) are related to cognitive impairment. Continuous positive airway pressure (CPAP) treatment can improve the clinical symptoms of OSA. Therefore, this study aimed to investigate functional connectivity (FC) changes in hippocampal subregions of patients with OSA after six months of CPAP treatment (post-CPAP) and its relationship with neurocognitive function. We collected and analyzed baseline (pre-CPAP) and post-CPAP data from 20 patients with OSA, including sleep monitoring, clinical evaluation, and resting-state functional magnetic resonance imaging. The results showed that compared with pre-CPAP OSA patients, the FC between the right anterior hippocampal gyrus and multiple brain regions, and between the left anterior hippocampal gyrus and posterior central gyrus were reduced in post-CPAP OSA patients. By contrast, the FC between the left middle hippocampus and the left precentral gyrus was increased. The changes in FC in these brain regions were closely related to cognitive dysfunction. Therefore, our findings suggest that CPAP treatment can effectively change the FC patterns of hippocampal subregions in patients with OSA, facilitating a better understanding of the neural mechanisms of cognitive function improvement, and emphasizing the importance of early diagnosis and timely treatment of OSA.https://www.mdpi.com/2076-3425/13/5/838obstructive sleep apneacontinuous positive airway pressureresting-state fMRIhippocampus subregionsfunctional connectivitycognitive impairment |
| spellingShingle | Ling Huang Haijun Li Yongqiang Shu Kunyao Li Wei Xie Yaping Zeng Ting Long Li Zeng Xiang Liu Dechang Peng Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment Brain Sciences obstructive sleep apnea continuous positive airway pressure resting-state fMRI hippocampus subregions functional connectivity cognitive impairment |
| title | Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment |
| title_full | Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment |
| title_fullStr | Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment |
| title_full_unstemmed | Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment |
| title_short | Changes in Functional Connectivity of Hippocampal Subregions in Patients with Obstructive Sleep Apnea after Six Months of Continuous Positive Airway Pressure Treatment |
| title_sort | changes in functional connectivity of hippocampal subregions in patients with obstructive sleep apnea after six months of continuous positive airway pressure treatment |
| topic | obstructive sleep apnea continuous positive airway pressure resting-state fMRI hippocampus subregions functional connectivity cognitive impairment |
| url | https://www.mdpi.com/2076-3425/13/5/838 |
| work_keys_str_mv | AT linghuang changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT haijunli changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT yongqiangshu changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT kunyaoli changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT weixie changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT yapingzeng changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT tinglong changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT lizeng changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT xiangliu changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment AT dechangpeng changesinfunctionalconnectivityofhippocampalsubregionsinpatientswithobstructivesleepapneaaftersixmonthsofcontinuouspositiveairwaypressuretreatment |