Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells

Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells

Polyploid giant cancer cells (PGCC) constitute a transiently senescent subpopulation of cancer cells that arises in response to stress. PGCC are capable of generating progeny via a primitive, cleavage-like cell division that is dependent on the sphingolipid enzyme acid ceramidase (ASAH1). The goal o...

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Bibliographic Details
Main Authors: Ping Lu, Shai White-Gilbertson, Gyda Beeson, Craig Beeson, Besim Ogretmen, James Norris, Christina Voelkel-Johnson
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
sphingolipids: p53
polyploidy
ceramide
ceramide synthase
cancer
Online Access:https://www.mdpi.com/2072-6694/13/9/2212

Internet

https://www.mdpi.com/2072-6694/13/9/2212

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