Prognostic significance of microRNA miR-24 in cancers: a meta-analysis
The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 Oct...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
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| Series: | Bioengineered |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21655979.2021.1875662 |
| _version_ | 1798034128433577984 |
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| author | Rongqiang Liu Weihao Kong Shiyang Zheng Chenyu Yu Yajie Yu Yuling Xu Linsen Ye Yi Shao |
| author_facet | Rongqiang Liu Weihao Kong Shiyang Zheng Chenyu Yu Yajie Yu Yuling Xu Linsen Ye Yi Shao |
| author_sort | Rongqiang Liu |
| collection | DOAJ |
| description | The prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies that evaluated the prognostic value of miR-24 in tumors were included. The hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CI) were used to evaluate survival outcomes and clinical characteristics. All data analyses were implemented using STATA 12.0 software. A total of 17 studies from 15 articles involving 1705 patients were collected for the meta-analysis. The pooled analysis revealed that elevated miR-24 expression was obviously associated with poor overall survival (OS) (HR = 1.66, 95% CI: 1.20–2.31). Furthermore, we also found that elevated miR-24 expression was positively correlated with tumor size (large or small) and tumor stage (III–IV vs I–II). Elevated miR-24 expression indicates poor prognosis and may be a promising prognostic marker in different cancers. Our findings needed to be verified through further investigations. |
| first_indexed | 2024-04-11T20:39:58Z |
| format | Article |
| id | doaj.art-8a873691c74e4feaa30034526632b3c3 |
| institution | Directory Open Access Journal |
| issn | 2165-5979 2165-5987 |
| language | English |
| last_indexed | 2024-04-11T20:39:58Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Bioengineered |
| spelling | doaj.art-8a873691c74e4feaa30034526632b3c32022-12-22T04:04:14ZengTaylor & Francis GroupBioengineered2165-59792165-59872021-01-0112145046010.1080/21655979.2021.18756621875662Prognostic significance of microRNA miR-24 in cancers: a meta-analysisRongqiang Liu0Weihao Kong1Shiyang Zheng2Chenyu Yu3Yajie Yu4Yuling Xu5Linsen Ye6Yi Shao7The First Affiliated Hospital of Nanchang UniversityThe First Affiliated Hospital of Anhui Medical UniversityThe Third Affiliated Hospital of Guangzhou Medical UniversityThe First Affiliated Hospital of Nanchang UniversityThe First Affiliated Hospital of Nanchang UniversityThe First Affiliated Hospital of Nanchang UniversityThe Third Affiliated Hospital of Sun Yat-sen UniversityThe First Affiliated Hospital of Nanchang UniversityThe prognostic significance of miR-24 in tumors has not been determined. Therefore, we conducted a meta-analysis to systematically assess the correlation between miR-24 and its prognostic value in cancers PubMed, EMBASE, and Web of Science databases were used to search relevant articles (up to 1 October 2020). Studies that evaluated the prognostic value of miR-24 in tumors were included. The hazard ratio (HR) and odds ratio (OR) with 95% confidence intervals (CI) were used to evaluate survival outcomes and clinical characteristics. All data analyses were implemented using STATA 12.0 software. A total of 17 studies from 15 articles involving 1705 patients were collected for the meta-analysis. The pooled analysis revealed that elevated miR-24 expression was obviously associated with poor overall survival (OS) (HR = 1.66, 95% CI: 1.20–2.31). Furthermore, we also found that elevated miR-24 expression was positively correlated with tumor size (large or small) and tumor stage (III–IV vs I–II). Elevated miR-24 expression indicates poor prognosis and may be a promising prognostic marker in different cancers. Our findings needed to be verified through further investigations.http://dx.doi.org/10.1080/21655979.2021.1875662mir-24prognosiscancermeta-analysis |
| spellingShingle | Rongqiang Liu Weihao Kong Shiyang Zheng Chenyu Yu Yajie Yu Yuling Xu Linsen Ye Yi Shao Prognostic significance of microRNA miR-24 in cancers: a meta-analysis Bioengineered mir-24 prognosis cancer meta-analysis |
| title | Prognostic significance of microRNA miR-24 in cancers: a meta-analysis |
| title_full | Prognostic significance of microRNA miR-24 in cancers: a meta-analysis |
| title_fullStr | Prognostic significance of microRNA miR-24 in cancers: a meta-analysis |
| title_full_unstemmed | Prognostic significance of microRNA miR-24 in cancers: a meta-analysis |
| title_short | Prognostic significance of microRNA miR-24 in cancers: a meta-analysis |
| title_sort | prognostic significance of microrna mir 24 in cancers a meta analysis |
| topic | mir-24 prognosis cancer meta-analysis |
| url | http://dx.doi.org/10.1080/21655979.2021.1875662 |
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