Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

Abstract Background Avian β-defensins (AvBD) are cationic antimicrobial peptides (CAMP) with broad-spectrum antimicrobial activity, chemotactic property, and low host cytotoxicity. However, their bactericidal activity is greatly compromised under physiological salt concentrations which limits the us...

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Bibliographic Details
Main Authors: Ming Yang, Chunye Zhang, Michael Z. Zhang, Shuping Zhang
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Microbiology
Subjects:
Cationic antimicrobial peptides
Peptide design
Salt resistance
Antimicrobial activity
Multidrug-resistant Pseudomonas aeruginosa
Methicillin-resistant Staphylococcus pseudintermedius
Online Access:http://link.springer.com/article/10.1186/s12866-018-1190-z

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