One-step in vivo gene knock-out in porcine embryos using recombinant adeno-associated viruses

One-step in vivo gene knock-out in porcine embryos using recombinant adeno-associated viruses

Introduction: Gene-edited pigs have become prominent models for studying human disease mechanisms, gene therapy, and xenotransplantation. CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated 9 (CRISPR/Cas9) technology is a widely employed tool for generating gene-edit...

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Main Authors: Mengyu Gao, YuTing He, XingLong Zhu, WanLiu Peng, YanYan Zhou, Yang Deng, Guangneng Liao, Wei Ni, Yi Li, Jun Gao, Hong Bu, Jiayin Yang, Guang Yang, Yang Yang, Ji Bao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CRISPR/Cas9
recombinant adeno-associated viruses
embryo gene delivery
gene-edited pig
animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1376936/full

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