Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production
During development multicellular organisms must become sexually mature to reproduce. But what underlying developmental clock times this transition? Recent data shows that in fly larvae, nuclear-cytoplasmic trafficking of DHR4, a nuclear receptor, in response to Prothoraciotropic hormone (PTTH) sig...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00108/full |
| _version_ | 1818841702676299776 |
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| author | Kim F Rewitz Michael B. O'Connor |
| author_facet | Kim F Rewitz Michael B. O'Connor |
| author_sort | Kim F Rewitz |
| collection | DOAJ |
| description | During development multicellular organisms must become sexually mature to reproduce. But what underlying developmental clock times this transition? Recent data shows that in fly larvae, nuclear-cytoplasmic trafficking of DHR4, a nuclear receptor, in response to Prothoraciotropic hormone (PTTH) signaling is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition. |
| first_indexed | 2024-12-19T04:30:17Z |
| format | Article |
| id | doaj.art-8a8a886d6c3f491bb65a2beb6f6d0b65 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-19T04:30:17Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8a8a886d6c3f491bb65a2beb6f6d0b652022-12-21T20:35:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922011-12-01210.3389/fendo.2011.0010818318Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid productionKim F Rewitz0Michael B. O'Connor1Roskilde UniversityUniversity of MinnesotaDuring development multicellular organisms must become sexually mature to reproduce. But what underlying developmental clock times this transition? Recent data shows that in fly larvae, nuclear-cytoplasmic trafficking of DHR4, a nuclear receptor, in response to Prothoraciotropic hormone (PTTH) signaling is critical for producing the correct temporal pulses of steroid hormones that coordinate the juvenile-adult transition.http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00108/fullmetamorphosis20-hydroxyecdysonecritical wieghtCyp6t3DHR4PTTH |
| spellingShingle | Kim F Rewitz Michael B. O'Connor Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production Frontiers in Endocrinology metamorphosis 20-hydroxyecdysone critical wieght Cyp6t3 DHR4 PTTH |
| title | Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production |
| title_full | Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production |
| title_fullStr | Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production |
| title_full_unstemmed | Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production |
| title_short | Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production |
| title_sort | timing is everything ptth mediated dhr4 nucleocytoplasmic trafficking sets the tempo of drosophila steroid production |
| topic | metamorphosis 20-hydroxyecdysone critical wieght Cyp6t3 DHR4 PTTH |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00108/full |
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