Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar
Diabetes Melitus is a group of metabolic diseases characterized by hyperglycemia due to lack of insulin secretion or insulin activity resistance. Chronic hyperglycemia in diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the kidneys, kidneys, nerves...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Gadjah Mada
2019-12-01
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| Series: | Jurnal Sain Veteriner |
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| Online Access: | https://jurnal.ugm.ac.id/jsv/article/view/46837 |
| _version_ | 1811259666700697600 |
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| author | Rondius Solfaine Lailatul Muniroh Wida Wahidah Mubarokah |
| author_facet | Rondius Solfaine Lailatul Muniroh Wida Wahidah Mubarokah |
| author_sort | Rondius Solfaine |
| collection | DOAJ |
| description | Diabetes Melitus is a group of metabolic diseases characterized by hyperglycemia due to lack of insulin secretion or insulin activity resistance. Chronic hyperglycemia in diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the kidneys, kidneys, nerves, heart and blood vessels. The purpose of this study was to analyze the activity of Adiponektin, superoxide dismutase, malondialdehyde, and glucose level in Streptozotocin-induced diabetic wistar rats. All wistar rats were divided into 4 groups, control (D0), induction group (D1), thitonia extract dose 100 mg / kg bw (D2) and catechin dose 10 mg/kg bw (D3) for 7 days. Model diabetes were used by induction of streptozotocin (Stz) at dosage 60 mg / kg bw intraperitoneally (ip) for 7 days. On the 8th day after the treatment, all groups of rats were sacrificed for blood samples for measured levels of superoxide dismutase and malondialdehyde and Adiponektine protein using Elisa technique, and measure of glucose level with calorimetry technique. Statistical analysis of data to examine differences in treatment and control was conducted by one way Anova test with a 95% confidence level (α=0.05). The results showed that there were differences in glucose levels (p = 0.020) and Adiponektin (p = 0.001) between the control and treatment groups, but there were no differences in level of MDA (p = 0.103) and SOD (p = 0.207 ) between groups. Base on the results of the study concluded that the administration of Tithonia Diversifolia leaf extract could reduce blood sugar and Adiponectin concentrations significantly (p≤0.05) in streptozotocin-induced diabetic on rats. |
| first_indexed | 2024-04-12T18:34:58Z |
| format | Article |
| id | doaj.art-8a8ab260948a49da98f559b168df62e5 |
| institution | Directory Open Access Journal |
| issn | 2407-3733 |
| language | Indonesian |
| last_indexed | 2024-04-12T18:34:58Z |
| publishDate | 2019-12-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Jurnal Sain Veteriner |
| spelling | doaj.art-8a8ab260948a49da98f559b168df62e52022-12-22T03:20:57ZindUniversitas Gadjah MadaJurnal Sain Veteriner2407-37332019-12-0137214315010.22146/jsv.4683725741Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih WistarRondius Solfaine0Lailatul Muniroh1Wida Wahidah Mubarokah2Laboratorium Patologi, Fakultas Kedokteran Hewan, Universitas Wijaya Kusuma SurabayaDepartmen Gizi Masyarakat, Fakultas Kesehatan Masyarakat, Universitas AirlanggaPoliteknik pembangunan Pertanian Yogyakarta, MagelangDiabetes Melitus is a group of metabolic diseases characterized by hyperglycemia due to lack of insulin secretion or insulin activity resistance. Chronic hyperglycemia in diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the kidneys, kidneys, nerves, heart and blood vessels. The purpose of this study was to analyze the activity of Adiponektin, superoxide dismutase, malondialdehyde, and glucose level in Streptozotocin-induced diabetic wistar rats. All wistar rats were divided into 4 groups, control (D0), induction group (D1), thitonia extract dose 100 mg / kg bw (D2) and catechin dose 10 mg/kg bw (D3) for 7 days. Model diabetes were used by induction of streptozotocin (Stz) at dosage 60 mg / kg bw intraperitoneally (ip) for 7 days. On the 8th day after the treatment, all groups of rats were sacrificed for blood samples for measured levels of superoxide dismutase and malondialdehyde and Adiponektine protein using Elisa technique, and measure of glucose level with calorimetry technique. Statistical analysis of data to examine differences in treatment and control was conducted by one way Anova test with a 95% confidence level (α=0.05). The results showed that there were differences in glucose levels (p = 0.020) and Adiponektin (p = 0.001) between the control and treatment groups, but there were no differences in level of MDA (p = 0.103) and SOD (p = 0.207 ) between groups. Base on the results of the study concluded that the administration of Tithonia Diversifolia leaf extract could reduce blood sugar and Adiponectin concentrations significantly (p≤0.05) in streptozotocin-induced diabetic on rats.https://jurnal.ugm.ac.id/jsv/article/view/46837malondialdehydestreptozotocinsuperoxide dismutasetithonia diversifolia |
| spellingShingle | Rondius Solfaine Lailatul Muniroh Wida Wahidah Mubarokah Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar Jurnal Sain Veteriner malondialdehyde streptozotocin superoxide dismutase tithonia diversifolia |
| title | Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar |
| title_full | Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar |
| title_fullStr | Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar |
| title_full_unstemmed | Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar |
| title_short | Aktivitas Ekstrak Daun Tithonia Diversifolia Terhadap Regulasi Kadar Adiponektin pada Diabetes Melitus Tikus Putih Wistar |
| title_sort | aktivitas ekstrak daun tithonia diversifolia terhadap regulasi kadar adiponektin pada diabetes melitus tikus putih wistar |
| topic | malondialdehyde streptozotocin superoxide dismutase tithonia diversifolia |
| url | https://jurnal.ugm.ac.id/jsv/article/view/46837 |
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