Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity
Background: S-methyl L-cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in Alium plants such as, garlic and onion. Objectives: The present study was aimed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats. M...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/3571/9-%207304_E(%20_%20)_F(H)_PF1(Pr_H)_PF1(MH)_PFA(P).pdf |
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| author | Senthilkumar G.P. Sithara Thomas Sivaraman K. Sankar P. Zachariah Bobby |
| author_facet | Senthilkumar G.P. Sithara Thomas Sivaraman K. Sankar P. Zachariah Bobby |
| author_sort | Senthilkumar G.P. |
| collection | DOAJ |
| description | Background: S-methyl L-cysteine (SMC) is a hydrophilic
cysteine-containing compound naturally found in Alium plants
such as, garlic and onion.
Objectives: The present study was aimed to evaluate the
hypoglycemic and antihyperlipidemic properties of SMC in high
fructose induced diabetic rats.
Material and Methods: The present study was designed to
evaluate the hypoglycemic and antihyperlipidemic properties
of SMC in high fructose induced diabetic rats. Blood samples
were collected and the fasting plasma glucose, lipid profile, total
antioxidant status (TAS) aspartate aminotransferase (AST) and
alanine aminotransferase (ALT) were estimated using standard
procedures. Differences between the groups were assessed by
using One way Analysis of Variance with (ANOVA) Tukey post
hoc test.
Results: Oral administration of SMC at a dose of 100 mg/kg
bodyweight/day to HFD-treated rats for a period of 60 days
showed significant reduction in the animal weight, fasting plasma
glucose, total cholesterol (TC), triglycerides (TG), low-density
lipoprotein cholesterol (LDL-C), VLDL-C and elevation in the level
of high-density lipoprotein cholesterol (HDL-C) and TAS compared
with fructose fed group. The effects of SMC was compared with
metformin; a well-known antihyperglycemic drug.
Conclusion: In conclusion, SMC found to be effective in
improving the high fructose induced hyperglycemia and
dyslipidemia. It may possibly provide a potential adjuvant for
the treatment and management of diabetes. |
| first_indexed | 2024-04-13T15:48:42Z |
| format | Article |
| id | doaj.art-8a8bf28659524ac0b5f3a1fa052b9d09 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T15:48:42Z |
| publishDate | 2013-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-8a8bf28659524ac0b5f3a1fa052b9d092022-12-22T02:40:54ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-11-017112449245110.7860/JCDR/2013/7304.3571Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced ObesitySenthilkumar G.P.0Sithara Thomas1Sivaraman K.2Sankar P.3Zachariah Bobby4Lecturer, Department of Biochemistry, JIPMER, Pondicherry- 605 006, India.Post Graduate, Medical Biochemistry Student, JIPMER, Pondicherry- 605 006, India.Post Graduate, Medical Biochemistry Student, JIPMER, Pondicherry- 605 006, India.Research Scholar, Department of Biochemistry, JIPMER, Pondicherry- 605 006, India.Additional Professor, Department of Biochemistry, JIPMER, Pondicherry- 605 006, India.Background: S-methyl L-cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in Alium plants such as, garlic and onion. Objectives: The present study was aimed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats. Material and Methods: The present study was designed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats. Blood samples were collected and the fasting plasma glucose, lipid profile, total antioxidant status (TAS) aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were estimated using standard procedures. Differences between the groups were assessed by using One way Analysis of Variance with (ANOVA) Tukey post hoc test. Results: Oral administration of SMC at a dose of 100 mg/kg bodyweight/day to HFD-treated rats for a period of 60 days showed significant reduction in the animal weight, fasting plasma glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), VLDL-C and elevation in the level of high-density lipoprotein cholesterol (HDL-C) and TAS compared with fructose fed group. The effects of SMC was compared with metformin; a well-known antihyperglycemic drug. Conclusion: In conclusion, SMC found to be effective in improving the high fructose induced hyperglycemia and dyslipidemia. It may possibly provide a potential adjuvant for the treatment and management of diabetes.https://jcdr.net/articles/PDF/3571/9-%207304_E(%20_%20)_F(H)_PF1(Pr_H)_PF1(MH)_PFA(P).pdfs-methyl l-cysteinehigh fructose diethypoglycemichypolipidemictotal antioxidant status |
| spellingShingle | Senthilkumar G.P. Sithara Thomas Sivaraman K. Sankar P. Zachariah Bobby Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity Journal of Clinical and Diagnostic Research s-methyl l-cysteine high fructose diet hypoglycemic hypolipidemic total antioxidant status |
| title | Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity |
| title_full | Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity |
| title_fullStr | Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity |
| title_full_unstemmed | Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity |
| title_short | Study the Effect of S-Methyl L-Cysteine on Lipid Metabolism in an Experimental Model of Diet Induced Obesity |
| title_sort | study the effect of s methyl l cysteine on lipid metabolism in an experimental model of diet induced obesity |
| topic | s-methyl l-cysteine high fructose diet hypoglycemic hypolipidemic total antioxidant status |
| url | https://jcdr.net/articles/PDF/3571/9-%207304_E(%20_%20)_F(H)_PF1(Pr_H)_PF1(MH)_PFA(P).pdf |
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