Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium
Thrombophilias are a group of coagulation disorders associated with a predisposition to thrombotic events. They could be inherited (genetic) or acquired. The most encountered inherited thrombophilias are factor V Leiden (FVL), prothrombin gene mutation (G20210A) (PGM), protein S deficiency, protein...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2020-12-01
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| Series: | Romanian Journal of Medical Practice |
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| Online Access: | https://rjmp.com.ro/articles/2020.4/RJMP_2020_4_Art-06.pdf |
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| author | Ana SCUTELNICU Corina GICA Radu BOTEZATU Nicolae GICA Anca Marina CIOBANU Brindusa CIMPOCA Gheorghe PELTECU Anca Maria PANAITESCU |
| author_facet | Ana SCUTELNICU Corina GICA Radu BOTEZATU Nicolae GICA Anca Marina CIOBANU Brindusa CIMPOCA Gheorghe PELTECU Anca Maria PANAITESCU |
| author_sort | Ana SCUTELNICU |
| collection | DOAJ |
| description | Thrombophilias are a group of coagulation disorders associated with a predisposition to thrombotic events.
They could be inherited (genetic) or acquired. The most encountered inherited thrombophilias are factor V Leiden (FVL), prothrombin gene mutation (G20210A) (PGM), protein S deficiency, protein C deficiency and antithrombin (AT) deficiency. Based upon the risk of thrombosis, there are two types of inherited thrombophilias, high risk and low risk. The high risk inherited thrombophilia includes antithrombin III deficiency, factor V Leiden homozygotes, prothrombin gene mutation and compound heterozygotes FVL and PGM. The low risk thrombophilia includes factor V Leiden heterozygote, PGM heterozygote, protein C deficiency and protein S deficiency. The incidence of all thromboembolic events is estimated to approximately 1-2 per 1000 pregnancies and about an equal number are identified antepartum and in the puerperium.
Screening for thrombophilia in pregnancy is not universally recommended because of the low incidence of the condition and because it is not cost-effective. Some adverse pregnancy outcomes could be associated with some types of thrombophilia, but this association is weak and there is no reason to initiate extensive investigations or therapeutic measures. Both obstetricians and hematologists and women need to be correctly informed and avoid emotional decisions and unnecessary invasive treatments. |
| first_indexed | 2024-12-19T20:59:49Z |
| format | Article |
| id | doaj.art-8a8c2ca2bc25453883270a4419ec96a2 |
| institution | Directory Open Access Journal |
| issn | 1842-8258 2069-6108 |
| language | English |
| last_indexed | 2024-12-19T20:59:49Z |
| publishDate | 2020-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Medical Practice |
| spelling | doaj.art-8a8c2ca2bc25453883270a4419ec96a22022-12-21T20:05:51ZengAmaltea Medical Publishing HouseRomanian Journal of Medical Practice1842-82582069-61082020-12-0115440040410.37897/RJMP.2020.4.6Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperiumAna SCUTELNICU0Corina GICA1Radu BOTEZATU2Nicolae GICA3Anca Marina CIOBANU4Brindusa CIMPOCA5Gheorghe PELTECU6Anca Maria PANAITESCU7Filantropia Clinical Hospital, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaFilantropia Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaThrombophilias are a group of coagulation disorders associated with a predisposition to thrombotic events. They could be inherited (genetic) or acquired. The most encountered inherited thrombophilias are factor V Leiden (FVL), prothrombin gene mutation (G20210A) (PGM), protein S deficiency, protein C deficiency and antithrombin (AT) deficiency. Based upon the risk of thrombosis, there are two types of inherited thrombophilias, high risk and low risk. The high risk inherited thrombophilia includes antithrombin III deficiency, factor V Leiden homozygotes, prothrombin gene mutation and compound heterozygotes FVL and PGM. The low risk thrombophilia includes factor V Leiden heterozygote, PGM heterozygote, protein C deficiency and protein S deficiency. The incidence of all thromboembolic events is estimated to approximately 1-2 per 1000 pregnancies and about an equal number are identified antepartum and in the puerperium. Screening for thrombophilia in pregnancy is not universally recommended because of the low incidence of the condition and because it is not cost-effective. Some adverse pregnancy outcomes could be associated with some types of thrombophilia, but this association is weak and there is no reason to initiate extensive investigations or therapeutic measures. Both obstetricians and hematologists and women need to be correctly informed and avoid emotional decisions and unnecessary invasive treatments.https://rjmp.com.ro/articles/2020.4/RJMP_2020_4_Art-06.pdfpregnancypuerperiuminherited thrombophiliavenous thromboembolismprophylaxis |
| spellingShingle | Ana SCUTELNICU Corina GICA Radu BOTEZATU Nicolae GICA Anca Marina CIOBANU Brindusa CIMPOCA Gheorghe PELTECU Anca Maria PANAITESCU Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium Romanian Journal of Medical Practice pregnancy puerperium inherited thrombophilia venous thromboembolism prophylaxis |
| title | Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium |
| title_full | Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium |
| title_fullStr | Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium |
| title_full_unstemmed | Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium |
| title_short | Screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium |
| title_sort | screening for inherited thrombophilias and prophylaxis of venous thromboembolism in pregnancy and puerperium |
| topic | pregnancy puerperium inherited thrombophilia venous thromboembolism prophylaxis |
| url | https://rjmp.com.ro/articles/2020.4/RJMP_2020_4_Art-06.pdf |
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