Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers.

Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers.

Artesunate, an artemisinin-derived monomer, was reported to inhibit Cytomegalovirus (CMV) replication. We aimed to compare the in-vitro anti-CMV activity of several artemisinin-derived monomers and newly synthesized artemisinin dimers.Four artemisinin monomers and two novel artemisinin-derived dimer...

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Bibliographic Details
Main Authors: Ravit Arav-Boger, Ran He, Chuang-Jiun Chiou, Jianyong Liu, Lauren Woodard, Andrew Rosenthal, Lorraine Jones-Brando, Michael Forman, Gary Posner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2860993?pdf=render

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