An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study
Introduction: Warfarin is an oral anticoagulant which is associated with a decrease in Bone Mass Density (BMD). Aim: The study aimed to explore the prevalence of osteoporosis conditions in Malaysians with chronic warfarin patients using calcaneal quarter of Quantitative Ultrasound (QUS) machine...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9483/23829_CE[Ra1]_F(GH)_PF1(P_RK)_PFA(GH)_PF2(NE_SY_DK).pdf |
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| author | Aseel Hadi Abdulameer Syed Azhar Bin Syed Sulaiman Muhamad Bin Sk Abdul Kader |
| author_facet | Aseel Hadi Abdulameer Syed Azhar Bin Syed Sulaiman Muhamad Bin Sk Abdul Kader |
| author_sort | Aseel Hadi Abdulameer |
| collection | DOAJ |
| description | Introduction: Warfarin is an oral anticoagulant which is
associated with a decrease in Bone Mass Density (BMD).
Aim: The study aimed to explore the prevalence of osteoporosis
conditions in Malaysians with chronic warfarin patients using
calcaneal quarter of Quantitative Ultrasound (QUS) machine
and to investigate whether long-term sodium warfarin therapy
that antagonizes vitamin K is affecting the increasing rate of
osteoporosis in Penang and to find the risk factors of getting
osteoporosis among warfarin users and its non users.
Materials and Methods: A case-control study was conducted
among 130 patients using warfarin, attending the outpatient
clinic at Hospital Pulau Pinang. A convenience sampling
method was used to recruit the required sample. Another 140
subjects were selected from the community as a control group
(non-users of warfarin).
Results: This study showed that more than three-quarter
patients (82%) were at high risk of abnormal BMD. The warfarin
users were two times more likely to have a higher osteoporosis
risk compared to control group. Moreover, BMD has a negative
correlation with age, but has a positive correlation with Body
Mass Index (BMI). Patients showed a negative correlation with
a higher dose of warfarin intake.
Conclusion: This study concluded that osteopenia and osteoporosis are serious problems between users and non-users warfarin
in Penang. Therefore, it should be taken into consideration in the
Malaysian Health Ministry’s agenda. |
| first_indexed | 2024-04-11T23:07:38Z |
| format | Article |
| id | doaj.art-8a902cfead784d6388535a4b9f5f6169 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-11T23:07:38Z |
| publishDate | 2017-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-8a902cfead784d6388535a4b9f5f61692022-12-22T03:57:58ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-03-01113OC21OC2410.7860/JCDR/2017/23829.9483An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control StudyAseel Hadi Abdulameer0Syed Azhar Bin Syed Sulaiman1Muhamad Bin Sk Abdul Kader2Postgraduate Student, Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.Professor, Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Penang, Malaysia.Faculty, Department of Cardiology, Hospital Pulau Pinang, Malaysia.Introduction: Warfarin is an oral anticoagulant which is associated with a decrease in Bone Mass Density (BMD). Aim: The study aimed to explore the prevalence of osteoporosis conditions in Malaysians with chronic warfarin patients using calcaneal quarter of Quantitative Ultrasound (QUS) machine and to investigate whether long-term sodium warfarin therapy that antagonizes vitamin K is affecting the increasing rate of osteoporosis in Penang and to find the risk factors of getting osteoporosis among warfarin users and its non users. Materials and Methods: A case-control study was conducted among 130 patients using warfarin, attending the outpatient clinic at Hospital Pulau Pinang. A convenience sampling method was used to recruit the required sample. Another 140 subjects were selected from the community as a control group (non-users of warfarin). Results: This study showed that more than three-quarter patients (82%) were at high risk of abnormal BMD. The warfarin users were two times more likely to have a higher osteoporosis risk compared to control group. Moreover, BMD has a negative correlation with age, but has a positive correlation with Body Mass Index (BMI). Patients showed a negative correlation with a higher dose of warfarin intake. Conclusion: This study concluded that osteopenia and osteoporosis are serious problems between users and non-users warfarin in Penang. Therefore, it should be taken into consideration in the Malaysian Health Ministry’s agenda.https://jcdr.net/articles/PDF/9483/23829_CE[Ra1]_F(GH)_PF1(P_RK)_PFA(GH)_PF2(NE_SY_DK).pdfanticoagulant drugsbone mineral densityosteoporosisvitamin k |
| spellingShingle | Aseel Hadi Abdulameer Syed Azhar Bin Syed Sulaiman Muhamad Bin Sk Abdul Kader An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study Journal of Clinical and Diagnostic Research anticoagulant drugs bone mineral density osteoporosis vitamin k |
| title | An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study |
| title_full | An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study |
| title_fullStr | An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study |
| title_full_unstemmed | An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study |
| title_short | An Assessment of Osteoporotic Conditions among Users and Non-Users of Warfarin: A Case-Control Study |
| title_sort | assessment of osteoporotic conditions among users and non users of warfarin a case control study |
| topic | anticoagulant drugs bone mineral density osteoporosis vitamin k |
| url | https://jcdr.net/articles/PDF/9483/23829_CE[Ra1]_F(GH)_PF1(P_RK)_PFA(GH)_PF2(NE_SY_DK).pdf |
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