LAPTM4B promotes the progression of nasopharyngeal cancer
Lysosomal protein transmembrane 4 beta (LAPTM4B) is a protein that contains four transmembrane domains. The impact of LAPTM4B on the malignancy of nasopharyngeal carcinoma (NPC) remains unclear. In the present study, we aimed to investigate the role of LAPTM4B in NPC. NPC tissue samples were used t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2021-06-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/4738 |
| _version_ | 1797261306765508608 |
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| author | Qun Su Hongtao Luo Ming Zhang Liying Gao Fengju Zhao |
| author_facet | Qun Su Hongtao Luo Ming Zhang Liying Gao Fengju Zhao |
| author_sort | Qun Su |
| collection | DOAJ |
| description |
Lysosomal protein transmembrane 4 beta (LAPTM4B) is a protein that contains four transmembrane domains. The impact of LAPTM4B on the malignancy of nasopharyngeal carcinoma (NPC) remains unclear. In the present study, we aimed to investigate the role of LAPTM4B in NPC. NPC tissue samples were used to evaluate the expression of LAPTM4B and its relationship with patient prognosis. Furthermore, we inhibited the expression of LAPTM4B in NPC cell lines and examined the effects of LAPTM4B on NPC cell proliferation, migration, and invasion. We found that LAPTM4B protein was mainly localized in the cytoplasm and intracellular membranes of NPC cells. LAPTM4B protein was upregulated in NPC tissues and cell lines. High LAPTM4B expression was closely related to pathological subtypes and disease stages in NPC patients. NPC patients with high LAPTM4B expression had a worse prognosis. LAPTM4B knockdown inhibited the proliferation, migration, and invasion ability of NPC cells. LAPTM4B plays a cancer-promoting role in the progression of NPC and may be a potential target for NPC therapy.
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| first_indexed | 2024-04-24T23:39:08Z |
| format | Article |
| id | doaj.art-8a90c3a57b1b4680ba2193115fce2a67 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:08Z |
| publishDate | 2021-06-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-8a90c3a57b1b4680ba2193115fce2a672024-03-15T13:44:21ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2021-06-0121310.17305/bjbms.2020.4738LAPTM4B promotes the progression of nasopharyngeal cancerQun Su0https://orcid.org/0000-0002-6023-3784Hongtao Luo1https://orcid.org/0000-0003-1835-1071Ming Zhang2https://orcid.org/0000-0002-2985-3977Liying Gao3https://orcid.org/0000-0002-0528-1097Fengju Zhao4https://orcid.org/0000-0002-5235-2599Department of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, ChinaDepartment of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, ChinaDepartment of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, ChinaDepartment of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, ChinaDepartment of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, China Lysosomal protein transmembrane 4 beta (LAPTM4B) is a protein that contains four transmembrane domains. The impact of LAPTM4B on the malignancy of nasopharyngeal carcinoma (NPC) remains unclear. In the present study, we aimed to investigate the role of LAPTM4B in NPC. NPC tissue samples were used to evaluate the expression of LAPTM4B and its relationship with patient prognosis. Furthermore, we inhibited the expression of LAPTM4B in NPC cell lines and examined the effects of LAPTM4B on NPC cell proliferation, migration, and invasion. We found that LAPTM4B protein was mainly localized in the cytoplasm and intracellular membranes of NPC cells. LAPTM4B protein was upregulated in NPC tissues and cell lines. High LAPTM4B expression was closely related to pathological subtypes and disease stages in NPC patients. NPC patients with high LAPTM4B expression had a worse prognosis. LAPTM4B knockdown inhibited the proliferation, migration, and invasion ability of NPC cells. LAPTM4B plays a cancer-promoting role in the progression of NPC and may be a potential target for NPC therapy. https://www.bjbms.org/ojs/index.php/bjbms/article/view/4738NPCLAPTM4Bprognosisproliferationmigrationinvasion |
| spellingShingle | Qun Su Hongtao Luo Ming Zhang Liying Gao Fengju Zhao LAPTM4B promotes the progression of nasopharyngeal cancer Biomolecules & Biomedicine NPC LAPTM4B prognosis proliferation migration invasion |
| title | LAPTM4B promotes the progression of nasopharyngeal cancer |
| title_full | LAPTM4B promotes the progression of nasopharyngeal cancer |
| title_fullStr | LAPTM4B promotes the progression of nasopharyngeal cancer |
| title_full_unstemmed | LAPTM4B promotes the progression of nasopharyngeal cancer |
| title_short | LAPTM4B promotes the progression of nasopharyngeal cancer |
| title_sort | laptm4b promotes the progression of nasopharyngeal cancer |
| topic | NPC LAPTM4B prognosis proliferation migration invasion |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/4738 |
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