An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects
Most of the allergenic proteins from fruits identified so far belong to different families of pathogenesis-related (PR) proteins. These PR proteins have been classified in different families of structurally and functionally unrelated proteins, but the majority of all fruit allergens belong to three...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Allergies |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-5786/3/3/10 |
| _version_ | 1797581598303977472 |
|---|---|
| author | Annick Barre Hervé Benoist Pierre Rougé |
| author_facet | Annick Barre Hervé Benoist Pierre Rougé |
| author_sort | Annick Barre |
| collection | DOAJ |
| description | Most of the allergenic proteins from fruits identified so far belong to different families of pathogenesis-related (PR) proteins. These PR proteins have been classified in different families of structurally and functionally unrelated proteins, but the majority of all fruit allergens belong to three groups, in particular PR-5 thaumatin-like proteins (TLP), PR-10 Bet v 1-like proteins, and PR-14 non-specific lipid transfer proteins (nsTLP). Some allergenic proteins from fruits can also be found among PR-protein families of PR-2 β1,3-glucanase proteins, PR-3 chitinases I, II, IV–VII, and PR-8 chitinases III. In addition, other important fruit allergens occur in protein families unrelated to the PR-protein families, such as the profilins and the newly emerging group of gibberellin-regulated proteins (GBRP). Finally, proteins that belong to seed storage proteins from higher plants, including 2S albumins, 7S globulins (vicilin), and 11S globulins (legumin), must be retained as possible potential fruit allergens resulting from the unintended consumption of the seeds. Here, we present an overview of the structural organization, functional properties, and phylogenetical relationships among these different groups of fruit allergens, supporting the occurrence of cross-reactivity and cross-allergenicity often described between fruit allergens, and the corresponding allergens from vegetables and pollens. |
| first_indexed | 2024-03-10T23:07:37Z |
| format | Article |
| id | doaj.art-8a90f8e263e64aa0a9f884b7fb1a5aef |
| institution | Directory Open Access Journal |
| issn | 2313-5786 |
| language | English |
| last_indexed | 2024-03-10T23:07:37Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Allergies |
| spelling | doaj.art-8a90f8e263e64aa0a9f884b7fb1a5aef2023-11-19T09:13:21ZengMDPI AGAllergies2313-57862023-07-013313417610.3390/allergies3030010An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical AspectsAnnick Barre0Hervé Benoist1Pierre Rougé2UMR 152 PharmaDev, Faculté de Pharmacie, Institut de Recherche et Développement, Université Paul, Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse, FranceUMR 152 PharmaDev, Faculté de Pharmacie, Institut de Recherche et Développement, Université Paul, Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse, FranceUMR 152 PharmaDev, Faculté de Pharmacie, Institut de Recherche et Développement, Université Paul, Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse, FranceMost of the allergenic proteins from fruits identified so far belong to different families of pathogenesis-related (PR) proteins. These PR proteins have been classified in different families of structurally and functionally unrelated proteins, but the majority of all fruit allergens belong to three groups, in particular PR-5 thaumatin-like proteins (TLP), PR-10 Bet v 1-like proteins, and PR-14 non-specific lipid transfer proteins (nsTLP). Some allergenic proteins from fruits can also be found among PR-protein families of PR-2 β1,3-glucanase proteins, PR-3 chitinases I, II, IV–VII, and PR-8 chitinases III. In addition, other important fruit allergens occur in protein families unrelated to the PR-protein families, such as the profilins and the newly emerging group of gibberellin-regulated proteins (GBRP). Finally, proteins that belong to seed storage proteins from higher plants, including 2S albumins, 7S globulins (vicilin), and 11S globulins (legumin), must be retained as possible potential fruit allergens resulting from the unintended consumption of the seeds. Here, we present an overview of the structural organization, functional properties, and phylogenetical relationships among these different groups of fruit allergens, supporting the occurrence of cross-reactivity and cross-allergenicity often described between fruit allergens, and the corresponding allergens from vegetables and pollens.https://www.mdpi.com/2313-5786/3/3/10edible fruitfleshy fruitallergenallergen familypathogenesis-related protein familythaumatin-like protein |
| spellingShingle | Annick Barre Hervé Benoist Pierre Rougé An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects Allergies edible fruit fleshy fruit allergen allergen family pathogenesis-related protein family thaumatin-like protein |
| title | An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects |
| title_full | An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects |
| title_fullStr | An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects |
| title_full_unstemmed | An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects |
| title_short | An Overview of Fruit Allergens: Structural, Functional, Phylogenetical, and Clinical Aspects |
| title_sort | overview of fruit allergens structural functional phylogenetical and clinical aspects |
| topic | edible fruit fleshy fruit allergen allergen family pathogenesis-related protein family thaumatin-like protein |
| url | https://www.mdpi.com/2313-5786/3/3/10 |
| work_keys_str_mv | AT annickbarre anoverviewoffruitallergensstructuralfunctionalphylogeneticalandclinicalaspects AT hervebenoist anoverviewoffruitallergensstructuralfunctionalphylogeneticalandclinicalaspects AT pierrerouge anoverviewoffruitallergensstructuralfunctionalphylogeneticalandclinicalaspects AT annickbarre overviewoffruitallergensstructuralfunctionalphylogeneticalandclinicalaspects AT hervebenoist overviewoffruitallergensstructuralfunctionalphylogeneticalandclinicalaspects AT pierrerouge overviewoffruitallergensstructuralfunctionalphylogeneticalandclinicalaspects |