The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves
Extracorporeal shock wave therapy (ESWT) is a safe and effective treatment option for various pathologies of the musculoskeletal system. Many studies address the molecular and cellular mechanisms of action of ESWT. However, to date, no uniform concept could be established on this matter. In the pres...
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MDPI AG
2022-05-01
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Series: | Biomedicines |
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Online Access: | https://www.mdpi.com/2227-9059/10/5/1084 |
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author | Tobias Wuerfel Christoph Schmitz Leon L. J. Jokinen |
author_facet | Tobias Wuerfel Christoph Schmitz Leon L. J. Jokinen |
author_sort | Tobias Wuerfel |
collection | DOAJ |
description | Extracorporeal shock wave therapy (ESWT) is a safe and effective treatment option for various pathologies of the musculoskeletal system. Many studies address the molecular and cellular mechanisms of action of ESWT. However, to date, no uniform concept could be established on this matter. In the present study, we perform a systematic review of the effects of exposure of musculoskeletal tissue to extracorporeal shock waves (ESWs) reported in the literature. The key results are as follows: (i) compared to the effects of many other forms of therapy, the clinical benefit of ESWT does not appear to be based on a single mechanism; (ii) different tissues respond to the same mechanical stimulus in different ways; (iii) just because a mechanism of action of ESWT is described in a study does not automatically mean that this mechanism is relevant to the observed clinical effect; (iv) focused ESWs and radial ESWs seem to act in a similar way; and (v) even the most sophisticated research into the effects of exposure of musculoskeletal tissue to ESWs cannot substitute clinical research in order to determine the optimum intensity, treatment frequency and localization of ESWT. |
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institution | Directory Open Access Journal |
issn | 2227-9059 |
language | English |
last_indexed | 2024-03-10T03:17:35Z |
publishDate | 2022-05-01 |
publisher | MDPI AG |
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series | Biomedicines |
spelling | doaj.art-8a93a6cc42a14fa5a91110fbf73c59502023-11-23T10:10:48ZengMDPI AGBiomedicines2227-90592022-05-01105108410.3390/biomedicines10051084The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock WavesTobias Wuerfel0Christoph Schmitz1Leon L. J. Jokinen2Extracorporeal Shock Wave Research Unit, Chair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-University of Munich, Munich 80336, GermanyExtracorporeal Shock Wave Research Unit, Chair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-University of Munich, Munich 80336, GermanyExtracorporeal Shock Wave Research Unit, Chair of Neuroanatomy, Institute of Anatomy, Faculty of Medicine, Ludwig-Maximilians-University of Munich, Munich 80336, GermanyExtracorporeal shock wave therapy (ESWT) is a safe and effective treatment option for various pathologies of the musculoskeletal system. Many studies address the molecular and cellular mechanisms of action of ESWT. However, to date, no uniform concept could be established on this matter. In the present study, we perform a systematic review of the effects of exposure of musculoskeletal tissue to extracorporeal shock waves (ESWs) reported in the literature. The key results are as follows: (i) compared to the effects of many other forms of therapy, the clinical benefit of ESWT does not appear to be based on a single mechanism; (ii) different tissues respond to the same mechanical stimulus in different ways; (iii) just because a mechanism of action of ESWT is described in a study does not automatically mean that this mechanism is relevant to the observed clinical effect; (iv) focused ESWs and radial ESWs seem to act in a similar way; and (v) even the most sophisticated research into the effects of exposure of musculoskeletal tissue to ESWs cannot substitute clinical research in order to determine the optimum intensity, treatment frequency and localization of ESWT.https://www.mdpi.com/2227-9059/10/5/1084extracorporeal shock wave therapyESWTfocused extracorporeal shock wave therapyfESWTmechanisms of actionradial extracorporeal shock wave therapy |
spellingShingle | Tobias Wuerfel Christoph Schmitz Leon L. J. Jokinen The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves Biomedicines extracorporeal shock wave therapy ESWT focused extracorporeal shock wave therapy fESWT mechanisms of action radial extracorporeal shock wave therapy |
title | The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves |
title_full | The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves |
title_fullStr | The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves |
title_full_unstemmed | The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves |
title_short | The Effects of the Exposure of Musculoskeletal Tissue to Extracorporeal Shock Waves |
title_sort | effects of the exposure of musculoskeletal tissue to extracorporeal shock waves |
topic | extracorporeal shock wave therapy ESWT focused extracorporeal shock wave therapy fESWT mechanisms of action radial extracorporeal shock wave therapy |
url | https://www.mdpi.com/2227-9059/10/5/1084 |
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