Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential
This paper demonstrates the role of curly kale fermentation by autochthonous lactic acid bacteria in the formation of bioactive derivatives of phenolic compounds which may have anticancer properties. LC-MS and HPLC analyses were performed and the content of polyphenols in curly kale before and durin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-04-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620300906 |
| _version_ | 1818871359259803648 |
|---|---|
| author | Magdalena Michalak Dominik Szwajgier Roman Paduch Wirginia Kukula-Koch Adam Waśko Magdalena Polak-Berecka |
| author_facet | Magdalena Michalak Dominik Szwajgier Roman Paduch Wirginia Kukula-Koch Adam Waśko Magdalena Polak-Berecka |
| author_sort | Magdalena Michalak |
| collection | DOAJ |
| description | This paper demonstrates the role of curly kale fermentation by autochthonous lactic acid bacteria in the formation of bioactive derivatives of phenolic compounds which may have anticancer properties. LC-MS and HPLC analyses were performed and the content of polyphenols in curly kale before and during fermentation were determined. Bioactive properties of salicylic and gentisic acids were tested in experiments on tumor (HT29, SW620) and normal (CCD841CoTr) epithelial cell lines. In this study, gentisic and salicylic acids were thoroughly examined. Gentisic acid has not been detected in Brasssicaceae vegetables so far, and the presence of both these acids was noted in fermented curly kale for the first time. Our results indicated that both salicylic and gentisic acids decreased the number of HT29 cells simultaneously with reduction of the intercellular interactions between these cells. Moreover, immunomodulatory and anti-inflammatory activity of gentisic acid was observed. |
| first_indexed | 2024-12-19T12:21:40Z |
| format | Article |
| id | doaj.art-8a9586495ec64f26afd3fed0cb33966c |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-19T12:21:40Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8a9586495ec64f26afd3fed0cb33966c2022-12-21T20:21:44ZengElsevierJournal of Functional Foods1756-46462020-04-0167103866Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potentialMagdalena Michalak0Dominik Szwajgier1Roman Paduch2Wirginia Kukula-Koch3Adam Waśko4Magdalena Polak-Berecka5Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, Poland; Corresponding author.Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, PolandDepartment of Virology and Immunology, Institute of Microbiology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19 Street, 20-033 Lublin, Poland; Department of General Ophthalmology, Medical University, Chmielna 1 Street, 20-079 Lublin, PolandDepartment of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Chodźki 1 Street, 20-093 Lublin, PolandDepartment of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, PolandDepartment of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Skromna 8 Street, 20-704 Lublin, PolandThis paper demonstrates the role of curly kale fermentation by autochthonous lactic acid bacteria in the formation of bioactive derivatives of phenolic compounds which may have anticancer properties. LC-MS and HPLC analyses were performed and the content of polyphenols in curly kale before and during fermentation were determined. Bioactive properties of salicylic and gentisic acids were tested in experiments on tumor (HT29, SW620) and normal (CCD841CoTr) epithelial cell lines. In this study, gentisic and salicylic acids were thoroughly examined. Gentisic acid has not been detected in Brasssicaceae vegetables so far, and the presence of both these acids was noted in fermented curly kale for the first time. Our results indicated that both salicylic and gentisic acids decreased the number of HT29 cells simultaneously with reduction of the intercellular interactions between these cells. Moreover, immunomodulatory and anti-inflammatory activity of gentisic acid was observed.http://www.sciencedirect.com/science/article/pii/S1756464620300906Curly kaleVegetable fermentationGentisic acidSalicylic acidPolyphenols metabolismBioactive properties |
| spellingShingle | Magdalena Michalak Dominik Szwajgier Roman Paduch Wirginia Kukula-Koch Adam Waśko Magdalena Polak-Berecka Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential Journal of Functional Foods Curly kale Vegetable fermentation Gentisic acid Salicylic acid Polyphenols metabolism Bioactive properties |
| title | Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential |
| title_full | Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential |
| title_fullStr | Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential |
| title_full_unstemmed | Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential |
| title_short | Fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential |
| title_sort | fermented curly kale as a new source of gentisic and salicylic acids with antitumor potential |
| topic | Curly kale Vegetable fermentation Gentisic acid Salicylic acid Polyphenols metabolism Bioactive properties |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620300906 |
| work_keys_str_mv | AT magdalenamichalak fermentedcurlykaleasanewsourceofgentisicandsalicylicacidswithantitumorpotential AT dominikszwajgier fermentedcurlykaleasanewsourceofgentisicandsalicylicacidswithantitumorpotential AT romanpaduch fermentedcurlykaleasanewsourceofgentisicandsalicylicacidswithantitumorpotential AT wirginiakukulakoch fermentedcurlykaleasanewsourceofgentisicandsalicylicacidswithantitumorpotential AT adamwasko fermentedcurlykaleasanewsourceofgentisicandsalicylicacidswithantitumorpotential AT magdalenapolakberecka fermentedcurlykaleasanewsourceofgentisicandsalicylicacidswithantitumorpotential |