The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals
Aquaporins constitute a group of water channel proteins located in numerous cell types. These are pore-forming transmembrane proteins, which mediate the specific passage of water molecules through membranes. It is well-known that water homeostasis plays a crucial role in different reproductive proce...
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MDPI AG
2020-12-01
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| author | Paweł Kordowitzki Wiesława Kranc Rut Bryl Bartosz Kempisty Agnieszka Skowronska Mariusz T. Skowronski |
| author_facet | Paweł Kordowitzki Wiesława Kranc Rut Bryl Bartosz Kempisty Agnieszka Skowronska Mariusz T. Skowronski |
| author_sort | Paweł Kordowitzki |
| collection | DOAJ |
| description | Aquaporins constitute a group of water channel proteins located in numerous cell types. These are pore-forming transmembrane proteins, which mediate the specific passage of water molecules through membranes. It is well-known that water homeostasis plays a crucial role in different reproductive processes, e.g., oocyte transport, hormonal secretion, completion of successful fertilization, blastocyst formation, pregnancy, and birth. Further, aquaporins are involved in the process of spermatogenesis, and they have been reported to be involved during the storage of spermatozoa. It is noteworthy that aquaporins are relevant for the physiological function of specific parts in the female reproductive system, which will be presented in detail in the first section of this review. Moreover, they are relevant in different pathologies in the female reproductive system. The contribution of aquaporins in selected reproductive disorders and aging will be summarized in the second section of this review, followed by a section dedicated to aquaporin-related proteins. Since the relevance of aquaporins for the male reproductive system has been reviewed several times in the recent past, this review aims to provide an update on the distribution and impact of aquaporins only in the female reproductive system. Therefore, this paper seeks to determine the physiological and patho-physiological relevance of aquaporins on female reproduction, and female reproductive aging. |
| first_indexed | 2024-03-10T14:24:25Z |
| format | Article |
| id | doaj.art-8a9685b2fe8a4e7f98fc7f4302c154e5 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:24:25Z |
| publishDate | 2020-12-01 |
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| spelling | doaj.art-8a9685b2fe8a4e7f98fc7f4302c154e52023-11-20T23:06:09ZengMDPI AGCells2073-44092020-12-01912257010.3390/cells9122570The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in MammalsPaweł Kordowitzki0Wiesława Kranc1Rut Bryl2Bartosz Kempisty3Agnieszka Skowronska4Mariusz T. Skowronski5Department of Basic and Preclinical Sciences, Institute for Veterinary Medicine, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Anatomy, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Warszawska Street 30, 10-082 Olsztyn, PolandDepartment of Basic and Preclinical Sciences, Institute for Veterinary Medicine, Nicolaus Copernicus University, 87-100 Torun, PolandAquaporins constitute a group of water channel proteins located in numerous cell types. These are pore-forming transmembrane proteins, which mediate the specific passage of water molecules through membranes. It is well-known that water homeostasis plays a crucial role in different reproductive processes, e.g., oocyte transport, hormonal secretion, completion of successful fertilization, blastocyst formation, pregnancy, and birth. Further, aquaporins are involved in the process of spermatogenesis, and they have been reported to be involved during the storage of spermatozoa. It is noteworthy that aquaporins are relevant for the physiological function of specific parts in the female reproductive system, which will be presented in detail in the first section of this review. Moreover, they are relevant in different pathologies in the female reproductive system. The contribution of aquaporins in selected reproductive disorders and aging will be summarized in the second section of this review, followed by a section dedicated to aquaporin-related proteins. Since the relevance of aquaporins for the male reproductive system has been reviewed several times in the recent past, this review aims to provide an update on the distribution and impact of aquaporins only in the female reproductive system. Therefore, this paper seeks to determine the physiological and patho-physiological relevance of aquaporins on female reproduction, and female reproductive aging.https://www.mdpi.com/2073-4409/9/12/2570female reproductive systemaquaporinphysiologyconnexingap-junctionsmammals |
| spellingShingle | Paweł Kordowitzki Wiesława Kranc Rut Bryl Bartosz Kempisty Agnieszka Skowronska Mariusz T. Skowronski The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals Cells female reproductive system aquaporin physiology connexin gap-junctions mammals |
| title | The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals |
| title_full | The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals |
| title_fullStr | The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals |
| title_full_unstemmed | The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals |
| title_short | The Relevance of Aquaporins for the Physiology, Pathology, and Aging of the Female Reproductive System in Mammals |
| title_sort | relevance of aquaporins for the physiology pathology and aging of the female reproductive system in mammals |
| topic | female reproductive system aquaporin physiology connexin gap-junctions mammals |
| url | https://www.mdpi.com/2073-4409/9/12/2570 |
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