Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP

<p>Abstract</p> <p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective loss of upper and lower motor neurons, a cell type that is intrinsically more vulnerable than other cell types to exogenous stress. The interplay between genet...

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Bibliographic Details
Main Authors: Aulas Anaïs, Stabile Stéphanie, Vande Velde Christine
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Molecular Neurodegeneration
Subjects:
TDP-43
Stress granules
FUS/TLS
G3BP
TIA-1
ALS
Cell death
Oxidative stress
Online Access:http://www.molecularneurodegeneration.com/content/7/1/54

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