Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma
Gastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumfer...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.934566/full |
| _version_ | 1828188438308847616 |
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| author | Arturo Bonometti Arturo Bonometti Arturo Bonometti Nicola Aronico Giovanni Santacroce Sara Fraticelli Marco Lucioni Marco Lucioni Claudio Salvatore Cartia Alessandro Vanoli Alessandro Vanoli Mario Andrea Latorre Luca Arcaini Luca Arcaini Marco Paulli Marco Paulli Antonio Di Sabatino |
| author_facet | Arturo Bonometti Arturo Bonometti Arturo Bonometti Nicola Aronico Giovanni Santacroce Sara Fraticelli Marco Lucioni Marco Lucioni Claudio Salvatore Cartia Alessandro Vanoli Alessandro Vanoli Mario Andrea Latorre Luca Arcaini Luca Arcaini Marco Paulli Marco Paulli Antonio Di Sabatino |
| author_sort | Arturo Bonometti |
| collection | DOAJ |
| description | Gastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumferential thickening of terminal ileum, for which the patient underwent an urgent 20-cm-long ileal resection. Histopathological and immunophenotypic analysis revealed a plasma cell neoplasm of the ileum. Subsequent investigations found a serum monoclonal immunoglobulin A component, an osteolytic lesion of the left jaw, and a clonal bone marrow plasma cell infiltrate carrying 1q21 amplification. Given the final diagnosis of plasma cell myeloma (PCM), the patient underwent a VMD (bortezomib, melphalan, and dexamethasone) chemotherapy regimen, achieving a complete remission after a 12-month treatment. For disease relapse, two further chemotherapy regimens were later attempted. At the last follow-up 4 years after the diagnosis, the patient is still alive. This case draws attention to the extramedullary presentation of plasma cell neoplasms, even if rare, as a prompt diagnosis seems to result in a better prognosis. In addition, it highlights the relevance of a multidisciplinary approach, involving gastroenterologists, hematologists, and pathologists, to the diagnosis and management of these neoplasms. |
| first_indexed | 2024-04-12T07:50:05Z |
| format | Article |
| id | doaj.art-8a9c32ec8ac44ef0a47406709d56017c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T07:50:05Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8a9c32ec8ac44ef0a47406709d56017c2022-12-22T03:41:37ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.934566934566Case Report: A rare case of small bowel obstruction secondary to plasma cell myelomaArturo Bonometti0Arturo Bonometti1Arturo Bonometti2Nicola Aronico3Giovanni Santacroce4Sara Fraticelli5Marco Lucioni6Marco Lucioni7Claudio Salvatore Cartia8Alessandro Vanoli9Alessandro Vanoli10Mario Andrea Latorre11Luca Arcaini12Luca Arcaini13Marco Paulli14Marco Paulli15Antonio Di Sabatino16Unit of Anatomic Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyPathology Unit, Humanitas Clinical and Research Center Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rozzano, ItalyFirst Department of Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyUnit of Anatomic Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDivision of Hematology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, ItalyUnit of Anatomic Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyDivision of Hematology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, ItalyUnit of Anatomic Pathology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, Pavia, ItalyFirst Department of Internal Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, University of Pavia, Pavia, ItalyGastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumferential thickening of terminal ileum, for which the patient underwent an urgent 20-cm-long ileal resection. Histopathological and immunophenotypic analysis revealed a plasma cell neoplasm of the ileum. Subsequent investigations found a serum monoclonal immunoglobulin A component, an osteolytic lesion of the left jaw, and a clonal bone marrow plasma cell infiltrate carrying 1q21 amplification. Given the final diagnosis of plasma cell myeloma (PCM), the patient underwent a VMD (bortezomib, melphalan, and dexamethasone) chemotherapy regimen, achieving a complete remission after a 12-month treatment. For disease relapse, two further chemotherapy regimens were later attempted. At the last follow-up 4 years after the diagnosis, the patient is still alive. This case draws attention to the extramedullary presentation of plasma cell neoplasms, even if rare, as a prompt diagnosis seems to result in a better prognosis. In addition, it highlights the relevance of a multidisciplinary approach, involving gastroenterologists, hematologists, and pathologists, to the diagnosis and management of these neoplasms.https://www.frontiersin.org/articles/10.3389/fonc.2022.934566/fullchemotherapyintestinal occlusionplasma cell myelomasmall bowelextramedullary presentation |
| spellingShingle | Arturo Bonometti Arturo Bonometti Arturo Bonometti Nicola Aronico Giovanni Santacroce Sara Fraticelli Marco Lucioni Marco Lucioni Claudio Salvatore Cartia Alessandro Vanoli Alessandro Vanoli Mario Andrea Latorre Luca Arcaini Luca Arcaini Marco Paulli Marco Paulli Antonio Di Sabatino Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma Frontiers in Oncology chemotherapy intestinal occlusion plasma cell myeloma small bowel extramedullary presentation |
| title | Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma |
| title_full | Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma |
| title_fullStr | Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma |
| title_full_unstemmed | Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma |
| title_short | Case Report: A rare case of small bowel obstruction secondary to plasma cell myeloma |
| title_sort | case report a rare case of small bowel obstruction secondary to plasma cell myeloma |
| topic | chemotherapy intestinal occlusion plasma cell myeloma small bowel extramedullary presentation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.934566/full |
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