The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis
PurposeTo evaluate and compare the value of conventional ultrasound-based superb microvascular imaging (SMI) and color Doppler flow imaging (CDFI) in the diagnosis of malignant thyroid nodule by meta-analysis.MethodsThe literature included in the Cochrane Library, PubMed, and Embase were searched by...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-06-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1182259/full |
| _version_ | 1797798417031757824 |
|---|---|
| author | Li Jiang Li Jiang Dian Zhang Yue-Nan Chen Xue-Juan Yu Mei-Fang Pan Lian Lian Lian Lian |
| author_facet | Li Jiang Li Jiang Dian Zhang Yue-Nan Chen Xue-Juan Yu Mei-Fang Pan Lian Lian Lian Lian |
| author_sort | Li Jiang |
| collection | DOAJ |
| description | PurposeTo evaluate and compare the value of conventional ultrasound-based superb microvascular imaging (SMI) and color Doppler flow imaging (CDFI) in the diagnosis of malignant thyroid nodule by meta-analysis.MethodsThe literature included in the Cochrane Library, PubMed, and Embase were searched by using “ superb microvascular imaging (SMI), color Doppler flow imaging (CDFI), ultrasound, thyroid nodules” as the keywords from inception through February 1, 2023. According to the inclusion and exclusion criteria, the clinical studies using SMI and CDFI to diagnose thyroid nodules were selected, and histopathology of thyroid nodules was used as reference standard. The diagnostic accuracy research quality assessment tool (QUADAS-2) was used to evaluate the quality of included literature, and the Review Manager 5.4 was used to make the quality evaluation chart. The heterogeneity test was performed on the literature that met the requirements, the combined sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were pooled, and a comprehensive ROC curve analysis was performed. Meta-DiSc version 1.4, StataSE 12, and Review Manager 5.4 software were used.ResultsFinally, 13 studies were included in this meta-analysis. A total of 815 thyroid malignant nodules were assessed. All thyroid nodules were histologically confirmed after SMI or CDFI. The combined sensitivity, specificity, PLR, NLR, DOR, and area under the SROC curve of SMI for the diagnosis of malignant thyroid nodules were 0.80(95%CI: 0.77-0.83), 0.79(95%CI: 0.77-0.82), 4.37(95%CI: 3.0-6.36), 0.23(95%CI: 0.15-0.35), 22.29(95%CI: 12.18-40.78), and 0.8944, respectively; the corresponding values of CDFI were 0.62(95%CI: 0.57-0.67), 0.81(95%CI: 0.78-0.85), 3.33(95%CI: 2.18-5.07), 0.41(95%CI: 0.27-0.64), 8.93(95%CI: 3.96-20.16), and 0.8498. Deek funnel pattern showed no significant publication bias.ConclusionThe diagnostic efficiency of SMI for malignant thyroid nodules is better than CDFI, and SMI technology can provide significantly more information on vascularity, make up for the deficiency of CDFI, and has better clinical application value.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023402064. |
| first_indexed | 2024-03-13T04:04:22Z |
| format | Article |
| id | doaj.art-8aa0259d2311458782352499e425ddfe |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T04:04:22Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8aa0259d2311458782352499e425ddfe2023-06-21T09:54:36ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-06-011410.3389/fendo.2023.11822591182259The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysisLi Jiang0Li Jiang1Dian Zhang2Yue-Nan Chen3Xue-Juan Yu4Mei-Fang Pan5Lian Lian6Lian Lian7Medical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Ultrasound, Suzhou Xiangcheng People’s Hospital, Jiangsu, ChinaDepartment of Ultrasound, Suzhou Xiangcheng People’s Hospital, Jiangsu, ChinaDepartment of Ultrasound, Suzhou Xiangcheng People’s Hospital, Jiangsu, ChinaDepartment of Ultrasound, Suzhou Xiangcheng People’s Hospital, Jiangsu, ChinaDepartment of Ultrasound, Suzhou Xiangcheng People’s Hospital, Jiangsu, ChinaMedical College, Yangzhou University, Yangzhou, Jiangsu, ChinaDepartment of Oncology, Suzhou Xiangcheng People’s Hospital, Jiangsu, ChinaPurposeTo evaluate and compare the value of conventional ultrasound-based superb microvascular imaging (SMI) and color Doppler flow imaging (CDFI) in the diagnosis of malignant thyroid nodule by meta-analysis.MethodsThe literature included in the Cochrane Library, PubMed, and Embase were searched by using “ superb microvascular imaging (SMI), color Doppler flow imaging (CDFI), ultrasound, thyroid nodules” as the keywords from inception through February 1, 2023. According to the inclusion and exclusion criteria, the clinical studies using SMI and CDFI to diagnose thyroid nodules were selected, and histopathology of thyroid nodules was used as reference standard. The diagnostic accuracy research quality assessment tool (QUADAS-2) was used to evaluate the quality of included literature, and the Review Manager 5.4 was used to make the quality evaluation chart. The heterogeneity test was performed on the literature that met the requirements, the combined sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio were pooled, and a comprehensive ROC curve analysis was performed. Meta-DiSc version 1.4, StataSE 12, and Review Manager 5.4 software were used.ResultsFinally, 13 studies were included in this meta-analysis. A total of 815 thyroid malignant nodules were assessed. All thyroid nodules were histologically confirmed after SMI or CDFI. The combined sensitivity, specificity, PLR, NLR, DOR, and area under the SROC curve of SMI for the diagnosis of malignant thyroid nodules were 0.80(95%CI: 0.77-0.83), 0.79(95%CI: 0.77-0.82), 4.37(95%CI: 3.0-6.36), 0.23(95%CI: 0.15-0.35), 22.29(95%CI: 12.18-40.78), and 0.8944, respectively; the corresponding values of CDFI were 0.62(95%CI: 0.57-0.67), 0.81(95%CI: 0.78-0.85), 3.33(95%CI: 2.18-5.07), 0.41(95%CI: 0.27-0.64), 8.93(95%CI: 3.96-20.16), and 0.8498. Deek funnel pattern showed no significant publication bias.ConclusionThe diagnostic efficiency of SMI for malignant thyroid nodules is better than CDFI, and SMI technology can provide significantly more information on vascularity, make up for the deficiency of CDFI, and has better clinical application value.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42023402064.https://www.frontiersin.org/articles/10.3389/fendo.2023.1182259/fullmalignantthyroid nodulesultrasonographySuperb microvascular imagingcolor Doppler flow imagingmeta-analysis |
| spellingShingle | Li Jiang Li Jiang Dian Zhang Yue-Nan Chen Xue-Juan Yu Mei-Fang Pan Lian Lian Lian Lian The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis Frontiers in Endocrinology malignant thyroid nodules ultrasonography Superb microvascular imaging color Doppler flow imaging meta-analysis |
| title | The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis |
| title_full | The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis |
| title_fullStr | The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis |
| title_full_unstemmed | The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis |
| title_short | The value of conventional ultrasound combined with superb microvascular imaging and color Doppler flow imaging in the diagnosis of thyroid malignant nodules: a systematic review and meta-analysis |
| title_sort | value of conventional ultrasound combined with superb microvascular imaging and color doppler flow imaging in the diagnosis of thyroid malignant nodules a systematic review and meta analysis |
| topic | malignant thyroid nodules ultrasonography Superb microvascular imaging color Doppler flow imaging meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1182259/full |
| work_keys_str_mv | AT lijiang thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lijiang thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT dianzhang thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT yuenanchen thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT xuejuanyu thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT meifangpan thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lianlian thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lianlian thevalueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lijiang valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lijiang valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT dianzhang valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT yuenanchen valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT xuejuanyu valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT meifangpan valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lianlian valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis AT lianlian valueofconventionalultrasoundcombinedwithsuperbmicrovascularimagingandcolordopplerflowimaginginthediagnosisofthyroidmalignantnodulesasystematicreviewandmetaanalysis |