Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer
We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into gr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/22/3621 |
| _version_ | 1797465651738050560 |
|---|---|
| author | Hui Wang Shanshan Zhao Chunyang Xu Jincao Yao Xiuhua Yu Dong Xu |
| author_facet | Hui Wang Shanshan Zhao Chunyang Xu Jincao Yao Xiuhua Yu Dong Xu |
| author_sort | Hui Wang |
| collection | DOAJ |
| description | We aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone. |
| first_indexed | 2024-03-09T18:25:30Z |
| format | Article |
| id | doaj.art-8aa44c75d9f04cb1b3ad6a5fb676dae3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T18:25:30Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8aa44c75d9f04cb1b3ad6a5fb676dae32023-11-24T07:58:22ZengMDPI AGCells2073-44092022-11-011122362110.3390/cells11223621Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid CancerHui Wang0Shanshan Zhao1Chunyang Xu2Jincao Yao3Xiuhua Yu4Dong Xu5Department of Ultrasound, Joint Service Support Force 903 Hospital, Hangzhou 310013, ChinaDepartment of Ultrasound, Shaoxing People’s Hospital, Shaoxing 312000, ChinaDepartment of General Surgery, Joint Service Support Force 903 Hospital, Hangzhou 310013, ChinaDepartment of Ultrasound, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou 310022, ChinaDepartment of Ultrasound, Joint Service Support Force 903 Hospital, Hangzhou 310013, ChinaDepartment of Ultrasound, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou 310022, ChinaWe aimed to determine factors influencing lymph node metastasis (LNM) and develop a more effective method to assess preoperative N staging. Overall, data of 2130 patients who underwent thyroidectomy for thyroid cancer between 2018 and 2021 were retrospectively analysed. Patients were divided into groups according to pN0, pN1a, and pN1b stages. Pathology was used to analyse the correlation between preoperative serum marker indicators and LNM. Receiver operating characteristic curves were used to compare the diagnostic value of ultrasound (US) examination alone, serum thyroglobulin, age, and combined method for LNM. A significant moderate agreement was observed between preoperative US and postoperative pathology for N staging. Between the pN0 and pN1 (pN1a + pN1b) groups, the differences in free triiodothyronine, anti-thyroid peroxidase antibody, and serum thyroglobulin levels were statistically significant. Among the indicators, serum thyroglobulin was an independent predictor of LNM. The area under the receiver operating characteristic curve was 0.610 for serum thyroglobulin level for predicting LNM, 0.689 for US alone, and 0.742 for the combined method. Both preoperative US and serum thyroglobulin level provide a specific value when evaluating the N staging of thyroid cancer, and the combined method is more valuable in the diagnosis of LNM than US alone.https://www.mdpi.com/2073-4409/11/22/3621lymph node metastasisneoplasm stagingthyroglobulinthyroid cancerultrasonography |
| spellingShingle | Hui Wang Shanshan Zhao Chunyang Xu Jincao Yao Xiuhua Yu Dong Xu Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer Cells lymph node metastasis neoplasm staging thyroglobulin thyroid cancer ultrasonography |
| title | Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer |
| title_full | Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer |
| title_fullStr | Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer |
| title_full_unstemmed | Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer |
| title_short | Clinical Value of Ultrasonography and Serum Markers in Preoperative N Staging of Thyroid Cancer |
| title_sort | clinical value of ultrasonography and serum markers in preoperative n staging of thyroid cancer |
| topic | lymph node metastasis neoplasm staging thyroglobulin thyroid cancer ultrasonography |
| url | https://www.mdpi.com/2073-4409/11/22/3621 |
| work_keys_str_mv | AT huiwang clinicalvalueofultrasonographyandserummarkersinpreoperativenstagingofthyroidcancer AT shanshanzhao clinicalvalueofultrasonographyandserummarkersinpreoperativenstagingofthyroidcancer AT chunyangxu clinicalvalueofultrasonographyandserummarkersinpreoperativenstagingofthyroidcancer AT jincaoyao clinicalvalueofultrasonographyandserummarkersinpreoperativenstagingofthyroidcancer AT xiuhuayu clinicalvalueofultrasonographyandserummarkersinpreoperativenstagingofthyroidcancer AT dongxu clinicalvalueofultrasonographyandserummarkersinpreoperativenstagingofthyroidcancer |