Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carv...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071&lng=en&tlng=en |
| _version_ | 1819263827859996672 |
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| author | Hossein Haddadi Ziba Rajaei Hojjatallah Alaei Somayeh Shahidani |
| author_facet | Hossein Haddadi Ziba Rajaei Hojjatallah Alaei Somayeh Shahidani |
| author_sort | Hossein Haddadi |
| collection | DOAJ |
| description | ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients. |
| first_indexed | 2024-12-23T20:19:47Z |
| format | Article |
| id | doaj.art-8aa45f61fbf547d69a7931c8cf3f2332 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-23T20:19:47Z |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-8aa45f61fbf547d69a7931c8cf3f23322022-12-21T17:32:34ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-4227762717710.1590/0004-282x20170193S0004-282X2018000200071Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's diseaseHossein HaddadiZiba RajaeiHojjatallah AlaeiSomayeh ShahidaniABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071&lng=en&tlng=enCarvacrol6-hidroxidopaminamemóriaatividade motorahiperalgesiadoença de Parkinson |
| spellingShingle | Hossein Haddadi Ziba Rajaei Hojjatallah Alaei Somayeh Shahidani Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease Arquivos de Neuro-Psiquiatria Carvacrol 6-hidroxidopamina memória atividade motora hiperalgesia doença de Parkinson |
| title | Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease |
| title_full | Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease |
| title_fullStr | Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease |
| title_full_unstemmed | Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease |
| title_short | Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease |
| title_sort | chronic treatment with carvacrol improves passive avoidance memory in a rat model of parkinson s disease |
| topic | Carvacrol 6-hidroxidopamina memória atividade motora hiperalgesia doença de Parkinson |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071&lng=en&tlng=en |
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