Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database
Objectives This study aimed to determine the relationship between the body mass index (BMI) and short-term mortality of patients with intra-abdominal infection (IAI) using the Medical Information Mart for Intensive Care (MIMIC-III) database.Design Retrospective cohort study.Setting Adult intensive c...
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| Format: | Article |
| Idioma: | English |
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BMJ Publishing Group
2021-08-01
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| Col·lecció: | BMJ Open |
| Accés en línia: | https://bmjopen.bmj.com/content/11/8/e046623.full |
| _version_ | 1826945271879172096 |
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| author | Chang Liu Yingmu Tong Sinan Liu Kaibo Yang Jingyao Zhang |
| author_facet | Chang Liu Yingmu Tong Sinan Liu Kaibo Yang Jingyao Zhang |
| author_sort | Chang Liu |
| collection | DOAJ |
| description | Objectives This study aimed to determine the relationship between the body mass index (BMI) and short-term mortality of patients with intra-abdominal infection (IAI) using the Medical Information Mart for Intensive Care (MIMIC-III) database.Design Retrospective cohort study.Setting Adult intensive care units (ICUs) at a tertiary hospital in the USA .Participants Adult IAI ICU patients from 2001 to 2012 in the MIMIC-III database.Interventions In univariate analysis, we compared the differences in the characteristics of patients in each BMI group. Cox regression models were used to evaluate the relationships between BMI and short-term prognosis.Primary and secondary outcome measures 90-day survival.Results In total, 1161 patients with IAI were included. There were 399 (34.4%) patients with a normal BMI (<25 kg/m2), 357 (30.8%) overweight patients (25–30 kg/m2) and 405 (34.9%) obese patients (>30 kg/m2) who tended to be younger (p<0.001) and had higher Sequential Organ Failure Assessment scores (p<0.05). The mortality of obese patients at 90 days was lower than that of patients with a normal BMI (20.74% vs 23.25%, p<0.05), but their length of stay in the ICU was higher (4.9 days vs 3.6 days, p<0.001); however, their rate of mechanical ventilation utilisation was higher (61.48% vs 56.86%, p<0.05). In the Cox regression model, we also confirmed that BMI was a protective factor in patients with IAIs, and the adjusted mortality rate of patients with a higher BMI was 0.97 times lower than that of patients with a lower BMI (p<0.001, HR=0.97, 95% CI 0.96 to 0.99).Conclusions IAI patients with an overweight or obese status might have lower 90-day mortality than patients with a normal BMI. |
| first_indexed | 2025-02-17T20:52:14Z |
| format | Article |
| id | doaj.art-8aa60ec9abf84ef98c69b78e6b3669b2 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2025-02-17T20:52:14Z |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-8aa60ec9abf84ef98c69b78e6b3669b22024-12-09T06:00:13ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2020-046623Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care databaseChang Liu0Yingmu Tong1Sinan Liu2Kaibo Yang3Jingyao Zhang4Department of Cardiology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi`an, Shaanxi, China1 Department of Forensic Medicine, School of Basic Medicine and Biological Sciences, Affiliated Guangji Hospital, Soochow University, Suzhou, Jiangsu, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi`an, Shaanxi, ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi`an, Shaanxi, ChinaObjectives This study aimed to determine the relationship between the body mass index (BMI) and short-term mortality of patients with intra-abdominal infection (IAI) using the Medical Information Mart for Intensive Care (MIMIC-III) database.Design Retrospective cohort study.Setting Adult intensive care units (ICUs) at a tertiary hospital in the USA .Participants Adult IAI ICU patients from 2001 to 2012 in the MIMIC-III database.Interventions In univariate analysis, we compared the differences in the characteristics of patients in each BMI group. Cox regression models were used to evaluate the relationships between BMI and short-term prognosis.Primary and secondary outcome measures 90-day survival.Results In total, 1161 patients with IAI were included. There were 399 (34.4%) patients with a normal BMI (<25 kg/m2), 357 (30.8%) overweight patients (25–30 kg/m2) and 405 (34.9%) obese patients (>30 kg/m2) who tended to be younger (p<0.001) and had higher Sequential Organ Failure Assessment scores (p<0.05). The mortality of obese patients at 90 days was lower than that of patients with a normal BMI (20.74% vs 23.25%, p<0.05), but their length of stay in the ICU was higher (4.9 days vs 3.6 days, p<0.001); however, their rate of mechanical ventilation utilisation was higher (61.48% vs 56.86%, p<0.05). In the Cox regression model, we also confirmed that BMI was a protective factor in patients with IAIs, and the adjusted mortality rate of patients with a higher BMI was 0.97 times lower than that of patients with a lower BMI (p<0.001, HR=0.97, 95% CI 0.96 to 0.99).Conclusions IAI patients with an overweight or obese status might have lower 90-day mortality than patients with a normal BMI.https://bmjopen.bmj.com/content/11/8/e046623.full |
| spellingShingle | Chang Liu Yingmu Tong Sinan Liu Kaibo Yang Jingyao Zhang Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database BMJ Open |
| title | Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database |
| title_full | Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database |
| title_fullStr | Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database |
| title_full_unstemmed | Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database |
| title_short | Association between body mass index and short-term mortality in patients with intra-abdominal infections: a retrospective, single-centre cohort study using the Medical Information Mart for Intensive Care database |
| title_sort | association between body mass index and short term mortality in patients with intra abdominal infections a retrospective single centre cohort study using the medical information mart for intensive care database |
| url | https://bmjopen.bmj.com/content/11/8/e046623.full |
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