A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center
Background: Correlation between chest X-ray findings and drug resistance can provide valuable guide for physicians working at low-resource settings. Objective: To study tuberculosis (TB) drug sensitivity pattern as per the radiological presentation. Materials and Methods: A hospital-based prospectiv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | MRIMS Journal of Health Sciences |
| Subjects: | |
| Online Access: | http://www.mrimsjournal.com/article.asp?issn=2321-7006;year=2023;volume=11;issue=1;spage=88;epage=93;aulast=Lal |
| _version_ | 1797902895163637760 |
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| author | Roshan Lal Chandra Shekhar Neeraj Kumar Kajal Chandrakar |
| author_facet | Roshan Lal Chandra Shekhar Neeraj Kumar Kajal Chandrakar |
| author_sort | Roshan Lal |
| collection | DOAJ |
| description | Background: Correlation between chest X-ray findings and drug resistance can provide valuable guide for physicians working at low-resource settings.
Objective: To study tuberculosis (TB) drug sensitivity pattern as per the radiological presentation.
Materials and Methods: A hospital-based prospective study was conducted among 67 newly diagnosed sputum-positive pulmonary TB patients who never took anti-TB treatment. They were subjected to history, systemic examination, radiology, and sputum smear examination. Ten patterns of chest X-ray were studied in the present study, which was not studied before. Chest X-ray radiology pattern was correlated with the drug resistance.
Results: Isoniazid (INH) monoresistance was present in 11.9% of patients. 1.5% had rifampicin (RIF) resistance but no INH resistance. RIF and INH both resistance (multidrug-resistant [MDR]) was present in 7.5% of cases. Pattern Four was the most common radiological presentation in our patients being present in 20 (29.9%) patients. In this pattern, bacteria of 5.0% were RIF resistant. 15.0% were INH resistant, and 5.0% were both RIF and INH resistant (MDR). RIF resistance was most common in chest X-ray PA view with “Pattern Two” being present in bacteria of 21.42% of patients.
Conclusion: Radiological patterns 2, 3, and 4 were highly correlated with the multidrug resistance, but it was not statistically significant. Patients' chest X-ray showing these patterns can be suspected to have MDR-TB and sent for further evaluation for early diagnosis and treatment of MDR-TB, which will give us good outcome. Further studies on this hypothesis should be conducted with bigger sample size to throw more light in this field. |
| first_indexed | 2024-04-10T09:24:29Z |
| format | Article |
| id | doaj.art-8aa6b95022f1485d99f3a0d337e1c690 |
| institution | Directory Open Access Journal |
| issn | 2321-7006 2321-7294 |
| language | English |
| last_indexed | 2024-04-10T09:24:29Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MRIMS Journal of Health Sciences |
| spelling | doaj.art-8aa6b95022f1485d99f3a0d337e1c6902023-02-20T07:23:04ZengWolters Kluwer Medknow PublicationsMRIMS Journal of Health Sciences2321-70062321-72942023-01-01111889310.4103/mjhs.mjhs_44_22A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy centerRoshan LalChandra ShekharNeeraj KumarKajal ChandrakarBackground: Correlation between chest X-ray findings and drug resistance can provide valuable guide for physicians working at low-resource settings. Objective: To study tuberculosis (TB) drug sensitivity pattern as per the radiological presentation. Materials and Methods: A hospital-based prospective study was conducted among 67 newly diagnosed sputum-positive pulmonary TB patients who never took anti-TB treatment. They were subjected to history, systemic examination, radiology, and sputum smear examination. Ten patterns of chest X-ray were studied in the present study, which was not studied before. Chest X-ray radiology pattern was correlated with the drug resistance. Results: Isoniazid (INH) monoresistance was present in 11.9% of patients. 1.5% had rifampicin (RIF) resistance but no INH resistance. RIF and INH both resistance (multidrug-resistant [MDR]) was present in 7.5% of cases. Pattern Four was the most common radiological presentation in our patients being present in 20 (29.9%) patients. In this pattern, bacteria of 5.0% were RIF resistant. 15.0% were INH resistant, and 5.0% were both RIF and INH resistant (MDR). RIF resistance was most common in chest X-ray PA view with “Pattern Two” being present in bacteria of 21.42% of patients. Conclusion: Radiological patterns 2, 3, and 4 were highly correlated with the multidrug resistance, but it was not statistically significant. Patients' chest X-ray showing these patterns can be suspected to have MDR-TB and sent for further evaluation for early diagnosis and treatment of MDR-TB, which will give us good outcome. Further studies on this hypothesis should be conducted with bigger sample size to throw more light in this field.http://www.mrimsjournal.com/article.asp?issn=2321-7006;year=2023;volume=11;issue=1;spage=88;epage=93;aulast=Laldirectly observed treatment short course chemotherapy (dots)lung diseaseresistancesensitivitytuberculosis |
| spellingShingle | Roshan Lal Chandra Shekhar Neeraj Kumar Kajal Chandrakar A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center MRIMS Journal of Health Sciences directly observed treatment short course chemotherapy (dots) lung disease resistance sensitivity tuberculosis |
| title | A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center |
| title_full | A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center |
| title_fullStr | A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center |
| title_full_unstemmed | A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center |
| title_short | A study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center |
| title_sort | study of rifampicin and isoniazid resistance in pulmonary tuberculosis patients with various radiological presentations at a designated microscopy center |
| topic | directly observed treatment short course chemotherapy (dots) lung disease resistance sensitivity tuberculosis |
| url | http://www.mrimsjournal.com/article.asp?issn=2321-7006;year=2023;volume=11;issue=1;spage=88;epage=93;aulast=Lal |
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