An interactive simulator to deepen the understanding of Guyton’s venous return curve
Abstract Mean circulatory filling pressure, venous return curve, and Guyton’s graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To deepen students’ understanding of the graphical an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Physiological Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12576-024-00912-9 |
| _version_ | 1797233763583787008 |
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| author | Noritaka Mamorita Akihiro Takeuchi Hirotoshi Kamata |
| author_facet | Noritaka Mamorita Akihiro Takeuchi Hirotoshi Kamata |
| author_sort | Noritaka Mamorita |
| collection | DOAJ |
| description | Abstract Mean circulatory filling pressure, venous return curve, and Guyton’s graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To deepen students’ understanding of the graphical analysis, in place of having to perform live animal experiments, we developed an interactive cardiovascular simulator, as a self-learning tool, as a web application. The minimum closed-loop model consisted of a ventricle, an artery, resistance, and a vein, excluding venous resistance. The simulator consists of three modules: setting (parameters and simulation modes), calculation, and presentation. In the setting module, the user can interactively customize model parameters, compliances, resistance, Emax of the ventricular contractility, total blood volume, and unstressed volume. The hemodynamics are calculated in three phases: filling (late diastole), ejection (systole), and flow (early diastole). In response to the user’s settings, the simulator graphically presents the hemodynamics: the pressure–volume relations of the artery, vein, and ventricle, the venous return curves, and the stroke volume curves. The mean filling pressure is calculated at approximately 7 mmHg at the initial setting. The venous return curves, linear and concave, are dependent on the venous compliance. The hemodynamic equilibrium point is marked on the crossing point of venous return curve and the stroke volume curve. Users can interactively do discovery learning, and try and confirm their interests and get their questions answered about hemodynamic concepts by using the simulator. |
| first_indexed | 2024-04-24T16:21:20Z |
| format | Article |
| id | doaj.art-8aa70e0b46154f7580cfead66c60c5a6 |
| institution | Directory Open Access Journal |
| issn | 1880-6562 |
| language | English |
| last_indexed | 2024-04-24T16:21:20Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj.art-8aa70e0b46154f7580cfead66c60c5a62024-03-31T11:12:38ZengBMCJournal of Physiological Sciences1880-65622024-03-0174111410.1186/s12576-024-00912-9An interactive simulator to deepen the understanding of Guyton’s venous return curveNoritaka Mamorita0Akihiro Takeuchi1Hirotoshi Kamata2Department of Medical Informatics, Kitasato University School of Allied Health SciencesDepartment of Medical Informatics, Kitasato University School of MedicineDepartment of Hematology, Kitasato University School of MedicineAbstract Mean circulatory filling pressure, venous return curve, and Guyton’s graphical analysis are basic concepts in cardiovascular physiology. However, some medical students may not know how to view and interpret or understand them adequately. To deepen students’ understanding of the graphical analysis, in place of having to perform live animal experiments, we developed an interactive cardiovascular simulator, as a self-learning tool, as a web application. The minimum closed-loop model consisted of a ventricle, an artery, resistance, and a vein, excluding venous resistance. The simulator consists of three modules: setting (parameters and simulation modes), calculation, and presentation. In the setting module, the user can interactively customize model parameters, compliances, resistance, Emax of the ventricular contractility, total blood volume, and unstressed volume. The hemodynamics are calculated in three phases: filling (late diastole), ejection (systole), and flow (early diastole). In response to the user’s settings, the simulator graphically presents the hemodynamics: the pressure–volume relations of the artery, vein, and ventricle, the venous return curves, and the stroke volume curves. The mean filling pressure is calculated at approximately 7 mmHg at the initial setting. The venous return curves, linear and concave, are dependent on the venous compliance. The hemodynamic equilibrium point is marked on the crossing point of venous return curve and the stroke volume curve. Users can interactively do discovery learning, and try and confirm their interests and get their questions answered about hemodynamic concepts by using the simulator.https://doi.org/10.1186/s12576-024-00912-9Cardiovascular modelVenous return curveMean circulatory filling pressureInteractive computer simulationJavaScriptWeb application |
| spellingShingle | Noritaka Mamorita Akihiro Takeuchi Hirotoshi Kamata An interactive simulator to deepen the understanding of Guyton’s venous return curve Journal of Physiological Sciences Cardiovascular model Venous return curve Mean circulatory filling pressure Interactive computer simulation JavaScript Web application |
| title | An interactive simulator to deepen the understanding of Guyton’s venous return curve |
| title_full | An interactive simulator to deepen the understanding of Guyton’s venous return curve |
| title_fullStr | An interactive simulator to deepen the understanding of Guyton’s venous return curve |
| title_full_unstemmed | An interactive simulator to deepen the understanding of Guyton’s venous return curve |
| title_short | An interactive simulator to deepen the understanding of Guyton’s venous return curve |
| title_sort | interactive simulator to deepen the understanding of guyton s venous return curve |
| topic | Cardiovascular model Venous return curve Mean circulatory filling pressure Interactive computer simulation JavaScript Web application |
| url | https://doi.org/10.1186/s12576-024-00912-9 |
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