The main pathogenetic mechanisms of vascular cerebral pathology associated with atherosclerosis and metabolic syndrome: the search for correction approaches
Metabolic syndrome (MS) is a risk factor for the developmentof acute and chronic vascular diseases of the brain. Oxidativestress developing under these conditions promotes the progressionof atherosclerotic disease of the brachiocephalic arteries,which necessitates correction of the identified pathob...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/65/93 |
| Summary: | Metabolic syndrome (MS) is a risk factor for the developmentof acute and chronic vascular diseases of the brain. Oxidativestress developing under these conditions promotes the progressionof atherosclerotic disease of the brachiocephalic arteries,which necessitates correction of the identified pathobiochemicalabnormalities. The use of antioxidant drugs in patients withcerebrovascular diseases and MS reduces manifestations of thelatter, including insulin resistance, hypertriglyceridemia, andhyperglycemia. The article presents the results of investigationof the drug mexidol in patients with chronic cerebrovascular diseasesassociated with atherosclerosis and MS. The findings demonstratethat drugs of this group have good prospects to be usedfor comprehensive correction of various pathogenic stages of thedeveloping pathology. |
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| ISSN: | 2075-5473 2409-2533 |