Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure
Aim. To study trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide (NT-proBNP) in the blood of patients with stage IIA and IIB chronic heart failure (CHF) during therapy aimed at reducing venous congestion. Material and methods. The study enrolled 52 patients with p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2011-01-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30793 |
| _version_ | 1818684422459752448 |
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| author | Elena Nikolaevna Egorova Margarita Ivanovna Kuz'mina Vera Vyacheslavovna Mazur Mikhail Nikolaevich Kalinkin Evgeniy Stanislavovich Mazur E N Egorova M I Kuzmina V V Mazur M N Kalinkin E S Mazur |
| author_facet | Elena Nikolaevna Egorova Margarita Ivanovna Kuz'mina Vera Vyacheslavovna Mazur Mikhail Nikolaevich Kalinkin Evgeniy Stanislavovich Mazur E N Egorova M I Kuzmina V V Mazur M N Kalinkin E S Mazur |
| author_sort | Elena Nikolaevna Egorova |
| collection | DOAJ |
| description | Aim. To study trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide (NT-proBNP) in the blood of patients with stage IIA and IIB chronic heart failure (CHF) during therapy aimed at reducing venous congestion.
Material and methods. The study enrolled 52 patients with postinfarction cardiosclerosis (PICS). Clinical, echocardiographic and laboratory studies were conducted. The levels of TNF-alpha, IL-6, IL-10 and C-reactive protein (CRP) were measured by enzyme immunoassay. The concentration of endotoxin (ET) was estimated by the end-point chromogenic LAL test, that of NT-proBNP - by immunochromotographic assay.
Results. In the patients with CHF, clinical signs of pulmonary venous congestion are associated with a statistically significant increase in the blood levels of TNF-alpha and CRP, those of systemic venous congestion are related to a further rise in TNF-alpha levels and elevation of blood concentrations of NT-proBNP, ET and IL-10. Treatment-related reduction in pulmonary venous congection is associated with a decrease in the levels of TNF-alpha, CRP and IL-6; that in systemic venous congestion - with lower concentrations of NT-proBNP, TNF-alpha and ET.
Conclusion. Specific changes in the levels of systemic inflammatory factors and NT-proBNP were found in patients with CHF in the presence of pulmonary and systemic venous congestion. Treatment aimed at elimination of the latter leads to reduction in the levels of systemic inflammatory factors and NT-proBNP. |
| first_indexed | 2024-12-17T10:50:23Z |
| format | Article |
| id | doaj.art-8aa8f90dc72d4d8a8a12c70d46ceb041 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-17T10:50:23Z |
| publishDate | 2011-01-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-8aa8f90dc72d4d8a8a12c70d46ceb0412022-12-21T21:52:00Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-01-01831565927809Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failureElena Nikolaevna EgorovaMargarita Ivanovna Kuz'minaVera Vyacheslavovna MazurMikhail Nikolaevich KalinkinEvgeniy Stanislavovich MazurE N Egorova0M I Kuzmina1V V Mazur2M N Kalinkin3E S Mazur4State Medical Academy, TverState Medical Academy, TverState Medical Academy, TverState Medical Academy, TverState Medical Academy, TverAim. To study trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide (NT-proBNP) in the blood of patients with stage IIA and IIB chronic heart failure (CHF) during therapy aimed at reducing venous congestion. Material and methods. The study enrolled 52 patients with postinfarction cardiosclerosis (PICS). Clinical, echocardiographic and laboratory studies were conducted. The levels of TNF-alpha, IL-6, IL-10 and C-reactive protein (CRP) were measured by enzyme immunoassay. The concentration of endotoxin (ET) was estimated by the end-point chromogenic LAL test, that of NT-proBNP - by immunochromotographic assay. Results. In the patients with CHF, clinical signs of pulmonary venous congestion are associated with a statistically significant increase in the blood levels of TNF-alpha and CRP, those of systemic venous congestion are related to a further rise in TNF-alpha levels and elevation of blood concentrations of NT-proBNP, ET and IL-10. Treatment-related reduction in pulmonary venous congection is associated with a decrease in the levels of TNF-alpha, CRP and IL-6; that in systemic venous congestion - with lower concentrations of NT-proBNP, TNF-alpha and ET. Conclusion. Specific changes in the levels of systemic inflammatory factors and NT-proBNP were found in patients with CHF in the presence of pulmonary and systemic venous congestion. Treatment aimed at elimination of the latter leads to reduction in the levels of systemic inflammatory factors and NT-proBNP.https://ter-arkhiv.ru/0040-3660/article/view/30793chronic heart failureaminoterminal brain natriuretic propeptidesystemic inflammatory factorscytokinesendotoxin |
| spellingShingle | Elena Nikolaevna Egorova Margarita Ivanovna Kuz'mina Vera Vyacheslavovna Mazur Mikhail Nikolaevich Kalinkin Evgeniy Stanislavovich Mazur E N Egorova M I Kuzmina V V Mazur M N Kalinkin E S Mazur Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure Терапевтический архив chronic heart failure aminoterminal brain natriuretic propeptide systemic inflammatory factors cytokines endotoxin |
| title | Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure |
| title_full | Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure |
| title_fullStr | Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure |
| title_full_unstemmed | Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure |
| title_short | Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure |
| title_sort | trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure |
| topic | chronic heart failure aminoterminal brain natriuretic propeptide systemic inflammatory factors cytokines endotoxin |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30793 |
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