Sex Differences in Brain and Cognition in de novo Parkinson's Disease
Background and Objective: Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease (PD) patients.Methods: Clinical, neuropsychological and T1-weighted MRI dat...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.791532/full |
| _version_ | 1798035261029875712 |
|---|---|
| author | Javier Oltra Javier Oltra Carme Uribe Carme Uribe Carme Uribe Anna Campabadal Anna Campabadal Anna Inguanzo Anna Inguanzo Gemma C. Monté-Rubio Maria J. Martí Maria J. Martí Maria J. Martí Yaroslau Compta Yaroslau Compta Yaroslau Compta Francesc Valldeoriola Francesc Valldeoriola Francesc Valldeoriola Carme Junque Carme Junque Carme Junque Barbara Segura Barbara Segura Barbara Segura |
| author_facet | Javier Oltra Javier Oltra Carme Uribe Carme Uribe Carme Uribe Anna Campabadal Anna Campabadal Anna Inguanzo Anna Inguanzo Gemma C. Monté-Rubio Maria J. Martí Maria J. Martí Maria J. Martí Yaroslau Compta Yaroslau Compta Yaroslau Compta Francesc Valldeoriola Francesc Valldeoriola Francesc Valldeoriola Carme Junque Carme Junque Carme Junque Barbara Segura Barbara Segura Barbara Segura |
| author_sort | Javier Oltra |
| collection | DOAJ |
| description | Background and Objective: Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease (PD) patients.Methods: Clinical, neuropsychological and T1-weighted MRI data from 205 PD patients (127 males: 78 females) and 69 healthy controls (40 males: 29 females) were obtained from the PPMI dataset.Results: PD males had a greater motor and rapid eye movement sleep behavior disorder symptomatology than PD females. They also showed cortical thinning in postcentral and precentral regions, greater global cortical and subcortical atrophy and smaller volumes in thalamus, caudate, putamen, pallidum, hippocampus, and brainstem, compared with PD females. Healthy controls only showed reduced hippocampal volume in males compared to females. PD males performed worse than PD females in global cognition, immediate verbal recall, and mental processing speed. In both groups males performed worse than females in semantic verbal fluency and delayed verbal recall; as well as females performed worse than males in visuospatial function.Conclusions: Sex effect in brain and cognition is already evident in de novo PD not explained by age per se, being a relevant factor to consider in clinical and translational research in PD. |
| first_indexed | 2024-04-11T20:55:45Z |
| format | Article |
| id | doaj.art-8aae13a0fde948f29ac4fef4f44c830d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-11T20:55:45Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-8aae13a0fde948f29ac4fef4f44c830d2022-12-22T04:03:42ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-01-011310.3389/fnagi.2021.791532791532Sex Differences in Brain and Cognition in de novo Parkinson's DiseaseJavier Oltra0Javier Oltra1Carme Uribe2Carme Uribe3Carme Uribe4Anna Campabadal5Anna Campabadal6Anna Inguanzo7Anna Inguanzo8Gemma C. Monté-Rubio9Maria J. Martí10Maria J. Martí11Maria J. Martí12Yaroslau Compta13Yaroslau Compta14Yaroslau Compta15Francesc Valldeoriola16Francesc Valldeoriola17Francesc Valldeoriola18Carme Junque19Carme Junque20Carme Junque21Barbara Segura22Barbara Segura23Barbara Segura24Medical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainResearch Imaging Centre, Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, University of Toronto, Toronto, ON, CanadaMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Hospital Clínic de Barcelona, Barcelona, SpainParkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Hospital Clínic de Barcelona, Barcelona, SpainParkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Hospital Clínic de Barcelona, Barcelona, SpainParkinson's Disease and Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Institute of Neurosciences, University of Barcelona, Barcelona, SpainMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Hospital Clínic de Barcelona, Barcelona, SpainMedical Psychology Unit, Department of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, SpainInstitute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Hospital Clínic de Barcelona, Barcelona, SpainBackground and Objective: Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease (PD) patients.Methods: Clinical, neuropsychological and T1-weighted MRI data from 205 PD patients (127 males: 78 females) and 69 healthy controls (40 males: 29 females) were obtained from the PPMI dataset.Results: PD males had a greater motor and rapid eye movement sleep behavior disorder symptomatology than PD females. They also showed cortical thinning in postcentral and precentral regions, greater global cortical and subcortical atrophy and smaller volumes in thalamus, caudate, putamen, pallidum, hippocampus, and brainstem, compared with PD females. Healthy controls only showed reduced hippocampal volume in males compared to females. PD males performed worse than PD females in global cognition, immediate verbal recall, and mental processing speed. In both groups males performed worse than females in semantic verbal fluency and delayed verbal recall; as well as females performed worse than males in visuospatial function.Conclusions: Sex effect in brain and cognition is already evident in de novo PD not explained by age per se, being a relevant factor to consider in clinical and translational research in PD.https://www.frontiersin.org/articles/10.3389/fnagi.2021.791532/fullParkinson's diseasesex differencesmagnetic resonance imaginggray matter atrophycognitive impairment |
| spellingShingle | Javier Oltra Javier Oltra Carme Uribe Carme Uribe Carme Uribe Anna Campabadal Anna Campabadal Anna Inguanzo Anna Inguanzo Gemma C. Monté-Rubio Maria J. Martí Maria J. Martí Maria J. Martí Yaroslau Compta Yaroslau Compta Yaroslau Compta Francesc Valldeoriola Francesc Valldeoriola Francesc Valldeoriola Carme Junque Carme Junque Carme Junque Barbara Segura Barbara Segura Barbara Segura Sex Differences in Brain and Cognition in de novo Parkinson's Disease Frontiers in Aging Neuroscience Parkinson's disease sex differences magnetic resonance imaging gray matter atrophy cognitive impairment |
| title | Sex Differences in Brain and Cognition in de novo Parkinson's Disease |
| title_full | Sex Differences in Brain and Cognition in de novo Parkinson's Disease |
| title_fullStr | Sex Differences in Brain and Cognition in de novo Parkinson's Disease |
| title_full_unstemmed | Sex Differences in Brain and Cognition in de novo Parkinson's Disease |
| title_short | Sex Differences in Brain and Cognition in de novo Parkinson's Disease |
| title_sort | sex differences in brain and cognition in de novo parkinson s disease |
| topic | Parkinson's disease sex differences magnetic resonance imaging gray matter atrophy cognitive impairment |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.791532/full |
| work_keys_str_mv | AT javieroltra sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT javieroltra sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT carmeuribe sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT carmeuribe sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT carmeuribe sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT annacampabadal sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT annacampabadal sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT annainguanzo sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT annainguanzo sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT gemmacmonterubio sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT mariajmarti sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT mariajmarti sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT mariajmarti sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT yaroslaucompta sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT yaroslaucompta sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT yaroslaucompta sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT francescvalldeoriola sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT francescvalldeoriola sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT francescvalldeoriola sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT carmejunque sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT carmejunque sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT carmejunque sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT barbarasegura sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT barbarasegura sexdifferencesinbrainandcognitionindenovoparkinsonsdisease AT barbarasegura sexdifferencesinbrainandcognitionindenovoparkinsonsdisease |