Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components
Neuropathic pain is a refractory disease that occurs across the world and pharmacotherapy has limited efficacy and/or safety. This disease imposes a significant burden on both the somatic and mental health of patients; indeed, some patients have referred to neuropathic pain as being ‘worse than deat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/1/255 |
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| author | Miao-Miao Tian Yu-Xiang Li Shan Liu Chun-Hao Zhu Xiao-Bing Lan Juan Du Lin Ma Jia-Mei Yang Ping Zheng Jian-Qiang Yu Ning Liu |
| author_facet | Miao-Miao Tian Yu-Xiang Li Shan Liu Chun-Hao Zhu Xiao-Bing Lan Juan Du Lin Ma Jia-Mei Yang Ping Zheng Jian-Qiang Yu Ning Liu |
| author_sort | Miao-Miao Tian |
| collection | DOAJ |
| description | Neuropathic pain is a refractory disease that occurs across the world and pharmacotherapy has limited efficacy and/or safety. This disease imposes a significant burden on both the somatic and mental health of patients; indeed, some patients have referred to neuropathic pain as being ‘worse than death’. The pharmacological agents that are used to treat neuropathic pain at present can produce mild effects in certain patients, and induce many adverse reactions, such as sedation, dizziness, vomiting, and peripheral oedema. Therefore, there is an urgent need to discover novel drugs that are safer and more effective. Natural compounds from medical plants have become potential sources of analgesics, and evidence has shown that glycosides alleviated neuropathic pain via regulating oxidative stress, transcriptional regulation, ion channels, membrane receptors and so on. In this review, we summarize the epidemiology of neuropathic pain and the existing therapeutic drugs used for disease prevention and treatment. We also demonstrate how glycosides exhibit an antinociceptive effect on neuropathic pain in laboratory research and describe the antinociceptive mechanisms involved to facilitate the discovery of new drugs to improve the quality of life of patients experiencing neuropathic pain. |
| first_indexed | 2024-03-10T03:30:02Z |
| format | Article |
| id | doaj.art-8aafa9f370ea4d44b73ee43641ef039c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:30:02Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8aafa9f370ea4d44b73ee43641ef039c2023-11-23T11:58:57ZengMDPI AGMolecules1420-30492021-12-0127125510.3390/molecules27010255Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal ComponentsMiao-Miao Tian0Yu-Xiang Li1Shan Liu2Chun-Hao Zhu3Xiao-Bing Lan4Juan Du5Lin Ma6Jia-Mei Yang7Ping Zheng8Jian-Qiang Yu9Ning Liu10Department of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaCollege of Nursing, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaDepartment of Pharmacology, School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, ChinaNeuropathic pain is a refractory disease that occurs across the world and pharmacotherapy has limited efficacy and/or safety. This disease imposes a significant burden on both the somatic and mental health of patients; indeed, some patients have referred to neuropathic pain as being ‘worse than death’. The pharmacological agents that are used to treat neuropathic pain at present can produce mild effects in certain patients, and induce many adverse reactions, such as sedation, dizziness, vomiting, and peripheral oedema. Therefore, there is an urgent need to discover novel drugs that are safer and more effective. Natural compounds from medical plants have become potential sources of analgesics, and evidence has shown that glycosides alleviated neuropathic pain via regulating oxidative stress, transcriptional regulation, ion channels, membrane receptors and so on. In this review, we summarize the epidemiology of neuropathic pain and the existing therapeutic drugs used for disease prevention and treatment. We also demonstrate how glycosides exhibit an antinociceptive effect on neuropathic pain in laboratory research and describe the antinociceptive mechanisms involved to facilitate the discovery of new drugs to improve the quality of life of patients experiencing neuropathic pain.https://www.mdpi.com/1420-3049/27/1/255neuropathic painepidemiologyglycosidesoxidative stresstranscriptional regulationion channels |
| spellingShingle | Miao-Miao Tian Yu-Xiang Li Shan Liu Chun-Hao Zhu Xiao-Bing Lan Juan Du Lin Ma Jia-Mei Yang Ping Zheng Jian-Qiang Yu Ning Liu Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components Molecules neuropathic pain epidemiology glycosides oxidative stress transcriptional regulation ion channels |
| title | Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components |
| title_full | Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components |
| title_fullStr | Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components |
| title_full_unstemmed | Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components |
| title_short | Glycosides for Peripheral Neuropathic Pain: A Potential Medicinal Components |
| title_sort | glycosides for peripheral neuropathic pain a potential medicinal components |
| topic | neuropathic pain epidemiology glycosides oxidative stress transcriptional regulation ion channels |
| url | https://www.mdpi.com/1420-3049/27/1/255 |
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