Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery
ObjectivesThe neutrophil gelatinase-associated lipocalin (NGAL) level following non cardiac surgery is useful for predicting acute kidney damage. However, there is insufficient conclusive evidence as to whether NGAL can be used to predict subclinical AKI following non-cardiac surgery. MethodsWe meas...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2017-12-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc032-02-07.pdf |
| _version_ | 1797989176321245184 |
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| author | Se Jun Park Hoseok Koo Kyoung Jin Lee Seo Hyun Kim Seo Young Yun Seunghyup Kim Dong Hee Whang Shin Young Joo Byungmo Lee HoJun Chin Sihyung Park |
| author_facet | Se Jun Park Hoseok Koo Kyoung Jin Lee Seo Hyun Kim Seo Young Yun Seunghyup Kim Dong Hee Whang Shin Young Joo Byungmo Lee HoJun Chin Sihyung Park |
| author_sort | Se Jun Park |
| collection | DOAJ |
| description | ObjectivesThe neutrophil gelatinase-associated lipocalin (NGAL) level following non cardiac surgery is useful for predicting acute kidney damage. However, there is insufficient conclusive evidence as to whether NGAL can be used to predict subclinical AKI following non-cardiac surgery. MethodsWe measured serum NGAL and creatinine levels in 41 patients following non-cardiac surgery, and the increase of these variables was used to predict acute decreases in kidney function. ResultsThe study included a total of 41 patients. The mean age was 64.65 ± 17.09 years. The serum creatinine concentration was increased 12 hours after surgery. The mean SD serum NGAL decreased after 4hours after surgery and continued to decrease after 12 hours after surgery. The incidence of subclinical AKI determined by the 4 hour serum NGAL level was 10(24.4%), and the incidence of serum creatinine elevation was 0(0.0%). The incidence of subclinical AKI determined by the 12 hour serum NGAL level was 4(9.8%), and the incidence of subclinical AKI determined by serum creatinine was 4(9.8%). The elevation of NGAL was more rapid than the serum creatinine 4 hours after surgery ConclusionsWe verified the usefulness of the serum NGAL level as a predictive factor for subclinical AKI after non-cardiac surgery. |
| first_indexed | 2024-04-11T08:16:04Z |
| format | Article |
| id | doaj.art-8aaff5d117da43898694df6257260a33 |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T08:16:04Z |
| publishDate | 2017-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-8aaff5d117da43898694df6257260a332022-12-22T04:35:10ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242017-12-0132221222010.7180/kmj.2017.32.2.212193Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgerySe Jun Park0Hoseok Koo1Kyoung Jin Lee2Seo Hyun Kim3Seo Young Yun4Seunghyup Kim5Dong Hee Whang6Shin Young Joo7Byungmo Lee8HoJun Chin9Sihyung Park10Department of Internal Medicine, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Internal Medicine, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Internal Medicine, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Internal Medicine, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Internal Medicine, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Internal Medicine, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Clinical Pathology, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Clinical Pathology, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Surgery, Inje University, Seoul Paik Hospital, Seoul, KoreaDepartment of Internal Medicine, Seoul National university Bundang Hospital, Gyeonggido, KoreaDepartment of Internal Medicine, Inje University, Haeundae Paik Hospital, Busan, KoreaObjectivesThe neutrophil gelatinase-associated lipocalin (NGAL) level following non cardiac surgery is useful for predicting acute kidney damage. However, there is insufficient conclusive evidence as to whether NGAL can be used to predict subclinical AKI following non-cardiac surgery. MethodsWe measured serum NGAL and creatinine levels in 41 patients following non-cardiac surgery, and the increase of these variables was used to predict acute decreases in kidney function. ResultsThe study included a total of 41 patients. The mean age was 64.65 ± 17.09 years. The serum creatinine concentration was increased 12 hours after surgery. The mean SD serum NGAL decreased after 4hours after surgery and continued to decrease after 12 hours after surgery. The incidence of subclinical AKI determined by the 4 hour serum NGAL level was 10(24.4%), and the incidence of serum creatinine elevation was 0(0.0%). The incidence of subclinical AKI determined by the 12 hour serum NGAL level was 4(9.8%), and the incidence of subclinical AKI determined by serum creatinine was 4(9.8%). The elevation of NGAL was more rapid than the serum creatinine 4 hours after surgery ConclusionsWe verified the usefulness of the serum NGAL level as a predictive factor for subclinical AKI after non-cardiac surgery.http://www.kosinmedj.org/upload/pdf/ksmc032-02-07.pdfacute kidney injurycreatininengalprognostic factorsurgery |
| spellingShingle | Se Jun Park Hoseok Koo Kyoung Jin Lee Seo Hyun Kim Seo Young Yun Seunghyup Kim Dong Hee Whang Shin Young Joo Byungmo Lee HoJun Chin Sihyung Park Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery Kosin Medical Journal acute kidney injury creatinine ngal prognostic factor surgery |
| title | Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery |
| title_full | Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery |
| title_fullStr | Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery |
| title_full_unstemmed | Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery |
| title_short | Usefulness of neutrophil gelatinase-associated lipocalin(NGAL) to confirm subclinical acute kidney injury and renal prognosis in patients following surgery |
| title_sort | usefulness of neutrophil gelatinase associated lipocalin ngal to confirm subclinical acute kidney injury and renal prognosis in patients following surgery |
| topic | acute kidney injury creatinine ngal prognostic factor surgery |
| url | http://www.kosinmedj.org/upload/pdf/ksmc032-02-07.pdf |
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