Relation of Gender to the Occurrence of AKI in STEMI Patients
Patients undergoing percutaneous coronary interventions (PCIs) are prone to a wide range of complications; one complication that is constantly correlated with a worse prognosis is acute kidney injury (AKI). Gender as an independent risk factor for said complications has raised some interest; however...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6565 |
| _version_ | 1797467725603274752 |
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| author | Shir Frydman Ophir Freund Ariel Banai Lior Zornitzki Shmuel Banai Yacov Shacham |
| author_facet | Shir Frydman Ophir Freund Ariel Banai Lior Zornitzki Shmuel Banai Yacov Shacham |
| author_sort | Shir Frydman |
| collection | DOAJ |
| description | Patients undergoing percutaneous coronary interventions (PCIs) are prone to a wide range of complications; one complication that is constantly correlated with a worse prognosis is acute kidney injury (AKI). Gender as an independent risk factor for said complications has raised some interest; however, studies have shown conflicting results so far. We aimed to investigate the possible relation of gender to the occurrence of AKI in STEMI patients undergoing PCI. This retrospective observational study cohort included 2967 consecutive patients admitted with STEMI between the years 2008 and 2019. Their renal outcomes were assessed according to KDIGO criteria (AKI serum creatinine ≥ 0.3 mg/dL from baseline within 48 h from admission), and in-hospital complications and mortality were reviewed. Our main results show that female patients were older (69 vs. 60, <i>p</i> < 0.001) and had higher rates of diabetes (29.2% vs. 23%, <i>p</i> < 0.001), hypertension (62.9% vs. 41.3%, <i>p</i> < 0.001), and chronic kidney disease (26.7% vs. 19.3%, <i>p</i> < 0.001). Females also had a higher rate of AKI (12.7% vs. 7.8%, <i>p</i> < 0.001), and among patients with AKI, severe AKI was also more prevalent in females (26.1% vs. 14.5%, <i>p</i> = 0.03). However, in multivariate analyses, after adjusting for the baseline characteristics above, the female gender was a non-significant predictor for AKI (adjusted OR 1.01, 95% CI 0.73–1.4, <i>p</i> = 0.94) or severe AKI (adjusted OR 1.65, 95% CI 0.80–1.65, <i>p</i> = 0.18). In conclusion, while females had higher rates of AKI and severe AKI, gender was not independently associated with AKI after adjusting for other confounding variables. Other comorbidities that are more prevalent in females can account for the difference in AKI between genders. |
| first_indexed | 2024-03-09T18:57:47Z |
| format | Article |
| id | doaj.art-8ab04d160d324baea8418ca8fe5e87d0 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:57:47Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8ab04d160d324baea8418ca8fe5e87d02023-11-24T05:19:46ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011121656510.3390/jcm11216565Relation of Gender to the Occurrence of AKI in STEMI PatientsShir Frydman0Ophir Freund1Ariel Banai2Lior Zornitzki3Shmuel Banai4Yacov Shacham5Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, IsraelDepartment of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 64239, IsraelPatients undergoing percutaneous coronary interventions (PCIs) are prone to a wide range of complications; one complication that is constantly correlated with a worse prognosis is acute kidney injury (AKI). Gender as an independent risk factor for said complications has raised some interest; however, studies have shown conflicting results so far. We aimed to investigate the possible relation of gender to the occurrence of AKI in STEMI patients undergoing PCI. This retrospective observational study cohort included 2967 consecutive patients admitted with STEMI between the years 2008 and 2019. Their renal outcomes were assessed according to KDIGO criteria (AKI serum creatinine ≥ 0.3 mg/dL from baseline within 48 h from admission), and in-hospital complications and mortality were reviewed. Our main results show that female patients were older (69 vs. 60, <i>p</i> < 0.001) and had higher rates of diabetes (29.2% vs. 23%, <i>p</i> < 0.001), hypertension (62.9% vs. 41.3%, <i>p</i> < 0.001), and chronic kidney disease (26.7% vs. 19.3%, <i>p</i> < 0.001). Females also had a higher rate of AKI (12.7% vs. 7.8%, <i>p</i> < 0.001), and among patients with AKI, severe AKI was also more prevalent in females (26.1% vs. 14.5%, <i>p</i> = 0.03). However, in multivariate analyses, after adjusting for the baseline characteristics above, the female gender was a non-significant predictor for AKI (adjusted OR 1.01, 95% CI 0.73–1.4, <i>p</i> = 0.94) or severe AKI (adjusted OR 1.65, 95% CI 0.80–1.65, <i>p</i> = 0.18). In conclusion, while females had higher rates of AKI and severe AKI, gender was not independently associated with AKI after adjusting for other confounding variables. Other comorbidities that are more prevalent in females can account for the difference in AKI between genders.https://www.mdpi.com/2077-0383/11/21/6565STEMIAKIgenderriskprognosismortality |
| spellingShingle | Shir Frydman Ophir Freund Ariel Banai Lior Zornitzki Shmuel Banai Yacov Shacham Relation of Gender to the Occurrence of AKI in STEMI Patients Journal of Clinical Medicine STEMI AKI gender risk prognosis mortality |
| title | Relation of Gender to the Occurrence of AKI in STEMI Patients |
| title_full | Relation of Gender to the Occurrence of AKI in STEMI Patients |
| title_fullStr | Relation of Gender to the Occurrence of AKI in STEMI Patients |
| title_full_unstemmed | Relation of Gender to the Occurrence of AKI in STEMI Patients |
| title_short | Relation of Gender to the Occurrence of AKI in STEMI Patients |
| title_sort | relation of gender to the occurrence of aki in stemi patients |
| topic | STEMI AKI gender risk prognosis mortality |
| url | https://www.mdpi.com/2077-0383/11/21/6565 |
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