MicroRNAs expression profile in CCR6+ regulatory T cells
Backgroud. CCR6+ CD4+ regulatory T cells (CCR6+ Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6+ Tr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2014-09-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/575.pdf |
| _version_ | 1827606162821873664 |
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| author | Juanjuan Zhao Yongju Li Yan Hu Chao Chen Ya Zhou Yijin Tao Mengmeng Guo Nalin Qin Lin Xu |
| author_facet | Juanjuan Zhao Yongju Li Yan Hu Chao Chen Ya Zhou Yijin Tao Mengmeng Guo Nalin Qin Lin Xu |
| author_sort | Juanjuan Zhao |
| collection | DOAJ |
| description | Backgroud. CCR6+ CD4+ regulatory T cells (CCR6+ Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6+ Tregs remains largely unknown. In this study, we detected the expression profile of miRNAs in CCR6+ Tregs.Materials and Methods. The expression profile of miRNAs as well as genes in CCR6+ Tregs or CCR6- Tregs from Balb/c mice were detected by microarray. The signaling pathways were analyzed using the Keggs pathway library.Results. We found that there were 58 miRNAs significantly upregulated and 62 downregulated up to 2 fold in CCR6+ Tregs compared with CCR6- Tregs. Moreover, 1,391 genes were observed with 3 fold change and 20 signaling pathways were enriched using the Keggs pathway library.Conclusion. The present data showed CCR6+ Tregs expressed specific miRNAs pattern, which provides insight into the role of miRNAs in the biological function of distinct Tregs subsets. |
| first_indexed | 2024-03-09T06:34:19Z |
| format | Article |
| id | doaj.art-8ab28312007e4dc9b4ff762e60740f4f |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:34:19Z |
| publishDate | 2014-09-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-8ab28312007e4dc9b4ff762e60740f4f2023-12-03T11:01:44ZengPeerJ Inc.PeerJ2167-83592014-09-012e57510.7717/peerj.575575MicroRNAs expression profile in CCR6+ regulatory T cellsJuanjuan Zhao0Yongju Li1Yan Hu2Chao Chen3Ya Zhou4Yijin Tao5Mengmeng Guo6Nalin Qin7Lin Xu8Department of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Medical Physics, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaDepartment of Immunology, Zunyi Medical College, Guizhou, ChinaBackgroud. CCR6+ CD4+ regulatory T cells (CCR6+ Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6+ Tregs remains largely unknown. In this study, we detected the expression profile of miRNAs in CCR6+ Tregs.Materials and Methods. The expression profile of miRNAs as well as genes in CCR6+ Tregs or CCR6- Tregs from Balb/c mice were detected by microarray. The signaling pathways were analyzed using the Keggs pathway library.Results. We found that there were 58 miRNAs significantly upregulated and 62 downregulated up to 2 fold in CCR6+ Tregs compared with CCR6- Tregs. Moreover, 1,391 genes were observed with 3 fold change and 20 signaling pathways were enriched using the Keggs pathway library.Conclusion. The present data showed CCR6+ Tregs expressed specific miRNAs pattern, which provides insight into the role of miRNAs in the biological function of distinct Tregs subsets.https://peerj.com/articles/575.pdfCCR6miRNAsRegulatory T cellMicroarray |
| spellingShingle | Juanjuan Zhao Yongju Li Yan Hu Chao Chen Ya Zhou Yijin Tao Mengmeng Guo Nalin Qin Lin Xu MicroRNAs expression profile in CCR6+ regulatory T cells PeerJ CCR6 miRNAs Regulatory T cell Microarray |
| title | MicroRNAs expression profile in CCR6+ regulatory T cells |
| title_full | MicroRNAs expression profile in CCR6+ regulatory T cells |
| title_fullStr | MicroRNAs expression profile in CCR6+ regulatory T cells |
| title_full_unstemmed | MicroRNAs expression profile in CCR6+ regulatory T cells |
| title_short | MicroRNAs expression profile in CCR6+ regulatory T cells |
| title_sort | micrornas expression profile in ccr6 regulatory t cells |
| topic | CCR6 miRNAs Regulatory T cell Microarray |
| url | https://peerj.com/articles/575.pdf |
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