Telomere Attrition in Isolated High-Grade Prostatic Intraepithelial Neoplasia and Surrounding Stroma Is Predictive of Prostate Cancer

Telomere Attrition in Isolated High-Grade Prostatic Intraepithelial Neoplasia and Surrounding Stroma Is Predictive of Prostate Cancer

The causes of early genomic events underlying the development of prostate cancer (CaP) remain unclear. The onset of chromosomal instability is likely to facilitate the formation of crucial genomic aberrations both in the precursor lesion high-grade prostatic intraepithelial neoplasia (HPIN) and in C...

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Bibliographic Details
Main Authors: Anthony Michael Joshua, Bisera Vukovic, Ilan Braudey, Sundus Hussein, Maria Zielenska, John Srigleyb, Andrew Evans, Jeremy Andrew Squire
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Genomic rearrangements
DNA imaging
quantitative FISH
preneoplasia
telomere
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800157

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