Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy
Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT). A significant portion of the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2009-12-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200003 |
| _version_ | 1828520370422939648 |
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| author | N.C. Nogueira-de-Souza I.D.C. Guerreiro da Silva C.V. de Carvalho A. Pulchinelli M.A. Haidar E.C. Baracat A.M. Massad-Costa |
| author_facet | N.C. Nogueira-de-Souza I.D.C. Guerreiro da Silva C.V. de Carvalho A. Pulchinelli M.A. Haidar E.C. Baracat A.M. Massad-Costa |
| author_sort | N.C. Nogueira-de-Souza |
| collection | DOAJ |
| description | Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT). A significant portion of the variability of these levels has been attributed to genetic factors. Therefore, we investigated the influence of estrogen receptor-alpha (ESR1) gene polymorphisms on HDL levels in response to postmenopausal HRT. We performed a prospective cohort study on 54 postmenopausal women who had not used HRT before the study and had no significant general medical illness. HRT consisted of conjugated equine estrogen and medroxyprogesterone acetate continuously for 1 year. The lipoprotein levels were measured from blood samples taken before the start of therapy and after 1 year of HRT. ESR1 polymorphism (MspI C>T, HaeIII C>T, PvuII C>T, and XbaI A>G) frequencies were assayed by restriction fragment length polymorphism. A general linear model was used to describe the relationships between HDL levels and genotypes after adjusting for age. A significant increase in HDL levels was observed after HRT (P = 0.029). Women with the ESR1 PvuII TT genotype showed a statistically significant increase in HDL levels after HRT (P = 0.032). No association was found between other ESR1 polymorphisms and HDL levels. According to our results, the ESR1 PvuII TT genotype was associated with increased levels of HDL after 1 year of HRT. |
| first_indexed | 2024-12-11T19:29:53Z |
| format | Article |
| id | doaj.art-8ab49ac2c70345729684c62a84378bdc |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-11T19:29:53Z |
| publishDate | 2009-12-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-8ab49ac2c70345729684c62a84378bdc2022-12-22T00:53:18ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2009-12-0142121138114210.1590/S0100-879X2009001200003Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapyN.C. Nogueira-de-SouzaI.D.C. Guerreiro da SilvaC.V. de CarvalhoA. PulchinelliM.A. HaidarE.C. BaracatA.M. Massad-CostaStudies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT). A significant portion of the variability of these levels has been attributed to genetic factors. Therefore, we investigated the influence of estrogen receptor-alpha (ESR1) gene polymorphisms on HDL levels in response to postmenopausal HRT. We performed a prospective cohort study on 54 postmenopausal women who had not used HRT before the study and had no significant general medical illness. HRT consisted of conjugated equine estrogen and medroxyprogesterone acetate continuously for 1 year. The lipoprotein levels were measured from blood samples taken before the start of therapy and after 1 year of HRT. ESR1 polymorphism (MspI C>T, HaeIII C>T, PvuII C>T, and XbaI A>G) frequencies were assayed by restriction fragment length polymorphism. A general linear model was used to describe the relationships between HDL levels and genotypes after adjusting for age. A significant increase in HDL levels was observed after HRT (P = 0.029). Women with the ESR1 PvuII TT genotype showed a statistically significant increase in HDL levels after HRT (P = 0.032). No association was found between other ESR1 polymorphisms and HDL levels. According to our results, the ESR1 PvuII TT genotype was associated with increased levels of HDL after 1 year of HRT.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200003Hormone replacement therapyHigh-density lipoprotein cholesterol levelsEstrogen receptor-alphaPolymorphism |
| spellingShingle | N.C. Nogueira-de-Souza I.D.C. Guerreiro da Silva C.V. de Carvalho A. Pulchinelli M.A. Haidar E.C. Baracat A.M. Massad-Costa Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy Brazilian Journal of Medical and Biological Research Hormone replacement therapy High-density lipoprotein cholesterol levels Estrogen receptor-alpha Polymorphism |
| title | Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy |
| title_full | Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy |
| title_fullStr | Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy |
| title_full_unstemmed | Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy |
| title_short | Effect of estrogen receptor-alpha (ESR1) gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy |
| title_sort | effect of estrogen receptor alpha esr1 gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy |
| topic | Hormone replacement therapy High-density lipoprotein cholesterol levels Estrogen receptor-alpha Polymorphism |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200003 |
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